Analysis of the Complete Genomes of Enterovirus 71 Subtypes in China.
Analysis of the Complete Genomes of Enterovirus 71 Subtypes in China.
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中国肠道病毒71亚型全基因组分析
DOI：
10.1155/2021/5564099
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Cui D
中科院分区：
文献类型：
--
作者：
Wang L;Dai Y;Cheng J;Sun C;Chen Y;Cui D
肠道病毒71型（EV-A71）是手足口病（HFMD）的主要病原体之一，也是婴幼儿神经系统并发症的主要病原体。EV-A71的分子特征对预防该病毒的暴发流行具有重要意义。在这里，从GenBank下载了1998年至2019年期间来自中国的EV-A71的完整基因组。应用MEGA7.0软件构建系统发育树，分析我国EV-A71的完整遗传流行病学特征和氨基酸突变情况。结果表明，2004年以前中国大陆EV-A71流行以C4 b亚型为主，2004年以后转为C4 a亚型;台湾地区EV-A71流行以C4和B5亚型为主。VP 1、VP 4、2C、3C、3D和全基因组序列可用于病毒基因分型，其中VP 1、VP 4和全基因组序列较其他片段具有明显优势。病毒全基因组序列中存在许多显著的突变。本研究表明，主要的C4和B5亚型将有助于EV-A71的疫苗和药物的开发，以预防和监测EV-A71相关的手足口病在中国。
Enterovirus 71 (EV-A71) is one of the most pathogens to hand, foot, and mouth disease (HFMD) as well as neurological complications in young children. Molecular characteristic of EV-A71 is important to prevent the virus outbreak. Here, the complete genomes of EV-A71 from China between 1998 and 2019 were downloaded from GenBank. The phylogenetic trees were developed by MEGA7.0 software, and the complete genetic epidemiological characteristics and amino acid mutations of EV-A71 from China were also analysed. The results showed that major epidemic EV-A71 subtype was C4b before 2004, while it turned to C4a after 2004 in mainland China, and C4 and B5 were major subtypes in Taiwan. VP1, VP4, 2C, 3C, 3D, and complete genome sequence can be used for virus genotyping, and VP1, VP4, and complete genomes have obvious advantages over other segments. There were many significant mutations in the viral complete genome sequence. This study indicated that the major C4 and B5 subtypes will contribute to the development of vaccines and drugs of EV-A71 for prevention and monitoring of EV-A71-associated HFMD in China.
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影响因子：
--
作者：
Castelló A;Alvarez E;Carrasco L
通讯作者：
Carrasco L
影响因子：
3.7
作者：
Ku Z;Ye X;Huang X;Cai Y;Liu Q;Li Y;Su Z;Huang Z
通讯作者：
Huang Z
影响因子：
4.8
作者：
Chen, Pan;Song, Zilin;Li, Wenhui
通讯作者：
Li, Wenhui
影响因子：
3.8
作者：
Huang ML;Chiang PS;Chia MY;Luo ST;Chang LY;Lin TY;Ho MS;Lee MS
通讯作者：
Lee MS
影响因子：
3.7
作者：
Chang HH;Tai TS;Lu B;Iannaccone C;Cernadas M;Weinblatt M;Shadick N;Miaw SC;Ho IC
通讯作者：
Ho IC