The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases.
The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases.
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DOI：
10.1155/2011/369648
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发表时间：
2011
影响因子：
--
通讯作者：
Carrasco L
中科院分区：
文献类型：
--
作者：
Castelló A;Alvarez E;Carrasco L
在进入动物细胞后，大多数病毒都会劫持参与基因表达的重要成分。脊髓灰质炎病毒就是这种情况，它在病毒内化后不久就取消了细胞翻译。通过病毒蛋白酶2A切割eIF4GI和eIF4GII来实现消除。除了脊髓灰质炎病毒对细胞蛋白质合成的干扰外，其他基因表达步骤，如RNA和蛋白质在细胞核和细胞质之间的运输也发生了变化。脊髓灰质炎病毒2Apro能够水解核孔的组分，从而阻止宿主细胞的有效抗病毒应答。在这里，我们详细比较了脊髓灰质炎病毒2Apro与其他病毒蛋白（来自小核糖核酸病毒和不相关家族）对控制基因表达的关键宿主因子的活性。未来确定2Apro靶向细胞蛋白的分析可能会发现脊髓灰质炎病毒感染所消除的其他细胞功能。对2Apro水解的细胞蛋白质的进一步了解将进一步深入了解脊髓灰质炎病毒和其他病毒与宿主细胞相互作用的分子机制。
After entry into animal cells, most viruses hijack essential components involved in gene expression. This is the case of poliovirus, which abrogates cellular translation soon after virus internalization. Abrogation is achieved by cleavage of both eIF4GI and eIF4GII by the viral protease 2A. Apart from the interference of poliovirus with cellular protein synthesis, other gene expression steps such as RNA and protein trafficking between nucleus and cytoplasm are also altered. Poliovirus 2Apro is capable of hydrolyzing components of the nuclear pore, thus preventing an efficient antiviral response by the host cell. Here, we compare in detail poliovirus 2Apro with other viral proteins (from picornaviruses and unrelated families) as regard to their activity on key host factors that control gene expression. It is possible that future analyses to determine the cellular proteins targeted by 2Apro will uncover other cellular functions ablated by poliovirus infection. Further understanding of the cellular proteins hydrolyzed by 2Apro will add further insight into the molecular mechanism by which poliovirus and other viruses interact with the host cell.
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DOI：
10.1006/bbrc.1995.1010
发表时间：
1995-01-05
影响因子：
3.1
作者：
ALDABE, R;CARRASCO, L
通讯作者：
CARRASCO, L
影响因子：
5.4
作者：
Barco, A;Feduchi, E;Carrasco, L
通讯作者：
Carrasco, L
影响因子：
5.4
作者：
BURROUGHS, JN;SANGAR, DV;COLLEN, D
通讯作者：
COLLEN, D
影响因子：
5.4
作者：
Belov, GA;Lidsky, PV;Agol, VI
通讯作者：
Agol, VI
DOI：
10.1006/bbrc.1995.2553
发表时间：
1995-10-24
影响因子：
3.1
作者：
ALDABE, R;FEDUCHI, E;CARRASCO, L
通讯作者：
CARRASCO, L