Polymodal roles of TRPC3 channel in the kidney.
Polymodal roles of TRPC3 channel in the kidney.
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DOI：
10.1080/19336950.2020.1804153
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Pochynyuk O
中科院分区：
文献类型：
--
作者：
Khayyat NH;Tomilin VN;Zaika O;Pochynyuk O
TRPC 3是一种Ca2+渗透性阳离子通道，通常由G蛋白偶联受体（GPCR）和质膜的机械变形激活。TRPC 3介导的Ca2+内流涉及可兴奋和不可兴奋细胞中的多种信号传导过程。肾脏在维持全身内环境稳定和设定血压方面起着指挥作用。TRPC3在肾血管系统和上皮细胞中大量表达，在那里它很好地定位于响应于GPCR依赖性内分泌刺激而介导信号传导和转运功能。此外，TRPC 3可以被肾小管流体流动和渗透压的动态变化引起的机械力激活。本综述批判性地分析了TRPC 3在肾脏不同部位的生理作用的现有已发表证据，并描述了TRPC 3消融的病理生理后果。我们还推测如何将这些证据进一步转化为临床。
TRPC3 is a Ca2+-permeable cation channel commonly activated by the G-protein coupled receptors (GPCR) and mechanical distortion of the plasma membrane. TRPC3-mediated Ca2+ influx has been implicated in a variety of signaling processes in both excitable and non-excitable cells. Kidneys play a commanding role in maintaining whole-body homeostasis and setting blood pressure. TRPC3 is expressed abundantly in the renal vasculature and in epithelial cells, where it is well positioned to mediate signaling and transport functions in response to GPCR-dependent endocrine stimuli. In addition, TRPC3 could be activated by mechanical forces resulting from dynamic changes in the renal tubule fluid flow and osmolarity. This review critically analyzes the available published evidence of the physiological roles of TRPC3 in different parts of the kidney and describes the pathophysiological ramifications of TRPC3 ablation. We also speculate how this evidence could be further translated into the clinic.
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