Orexin/hypocretin modulation of the basal forebrain cholinergic system: Role in attention.
Orexin/hypocretin modulation of the basal forebrain cholinergic system: Role in attention.
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DOI：
10.1016/j.brainres.2009.08.046
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发表时间：
2010-02-16
期刊：
影响因子：
2.9
通讯作者：
Burk, J. A.
中科院分区：
文献类型：
--
作者：
Fadel, J.;Burk, J. A.
基底前脑胆碱能系统（BFCS）在注意功能的几个方面发挥作用。不同的传入输入对该系统的激活可能会影响注意资源的分配。虽然人们已经认识到下丘脑是基底前脑投射的重要来源，但这些输入的表型以及它们对BFCS的调节在功能上相关的条件仍然不清楚。表达食欲素/下丘脑泌素神经肽的神经元的细胞体仅限于外侧下丘脑和邻近的穹窿周围区，但具有广泛的投射，包括基底前脑。食欲素纤维和两种食欲素受体亚型分布在基底前脑的胆碱能部分，其中应用食欲素肽增加细胞活性和皮质乙酰胆碱释放。此外，基底前脑中食欲素信号传导的中断损害了对食欲刺激的胆碱能反应。在这篇综述中，我们提出，食欲素输入的BFCS形成的唤醒和注意力之间的联系解剖基板，这些相互作用可能是特别重要的一种手段，通过这种手段，内感受性线索的偏见分配的注意力资源向相关的外感受性刺激。食欲素-乙酰胆碱相互作用的功能障碍可能在唤醒和注意力缺陷中发挥作用，这些缺陷伴随着神经退行性疾病，如药物成瘾和年龄相关的认知下降。
The basal forebrain cholinergic system (BFCS) plays a role in several aspects of attentional function. Activation of this system by different afferent inputs is likely to influence how attentional resources are allocated. While it has been recognized for some time that the hypothalamus is a significant source of projections to the basal forebrain, the phenotype(s) of these inputs and the conditions under which their regulation of the BFCS becomes functionally relevant are still unclear. The cell bodies of neurons expressing orexin/hypocretin neuropeptides are restricted to the lateral hypothalamus and contiguous perifornical area but have widespread projections, including to the basal forebrain. Orexin fibers and both orexin receptor subtypes are distributed in cholinergic parts of the basal forebrain, where application of orexin peptides increases cell activity and cortical acetylcholine release. Furthermore, disruption of orexin signaling in the basal forebrain impairs the cholinergic response to an appetitive stimulus. In this review, we propose that orexin inputs to the BFCS form an anatomical substrate for links between arousal and attention, and that these interactions might be particularly important as a means by which interoceptive cues bias allocation of attentional resources toward related exteroceptive stimuli. Dysfunction in orexin-acetylcholine interactions may play a role in the arousal and attentional deficits that accompany neurodegenerative conditions as diverse as drug addiction and age-related cognitive decline.
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DOI：
10.1073/pnas.0507480102
发表时间：
2005-12-27
影响因子：
11.1
作者：
Boutrel, B;Kenny, PJ;de Lecea, L
通讯作者：
de Lecea, L
DOI：
10.1111/j.1748-1716.2008.01922.x
发表时间：
2009-01
期刊：
Acta physiologica (Oxford, England)
影响因子：
--
作者：
Burdakov D;González JA
通讯作者：
González JA
影响因子：
3.3
作者：
Arnold, HM;Burk, JA;Bruno, JP
通讯作者：
Bruno, JP
影响因子：
16.2
作者：
Borgland, SL;Taha, SA;Bonci, A
通讯作者：
Bonci, A
影响因子：
3.4
作者：
Borgland, S. L.;Storm, E.;Bonci, A.
通讯作者：
Bonci, A.