Macroscopic Portal Vein Thrombosis in HCC Patients.
Macroscopic Portal Vein Thrombosis in HCC Patients.
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DOI：
10.1155/2018/3120185
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发表时间：
2018
影响因子：
2.7
通讯作者：
Kılıç M
中科院分区：
文献类型：
--
作者：
Akkiz H;Carr BI;Kuran S;Karaoğullarından Ü;Üsküdar O;Tokmak S;Arslan B;Doran F;Balli HT;Ülkü A;Akçam TA;Bahçeci Hİ;Polat KY;Örmeci N;Şimşek H;Sonsuz A;Demir A;Altıntaş E;Demir M;Yalçın K;Ekinci N;Harmancı Özakyol A;Yücesoy M;Uygun A;Guerra V;Delik A;Tokat Y;Yilmaz S;Bektaş A;Kılıç M
肝细胞癌（HCC）侵犯门静脉是影响HCC患者预后的重要因素之一。研究了一个大的此类患者队列的特征。我们发现，随着最大肿瘤直径（MTD）的增加，PVT患者的百分比显著增加，从13.7%的肿瘤MTD <5cm to 56.4% with tumors of MTD >10 cm。有类似数量的肝癌患者的非常大的肿瘤，并没有PVT。因此，MTD单独是不足以解释PVT的存在，高AFP水平，因为不到50%的高AFP患者有PVT。然而，PVT患者的百分比也被发现显着增加血液甲胎蛋白（AFP）水平和肿瘤多灶性。包括这3个因素的逻辑回归模型显示，与这3个参数的低水平相比，MTD>5.0cm+肿瘤多灶性+AFP升高的组合的优势比为17.9。因此，肉眼可见PVT的存在或不存在可能代表不同的HCC侵袭性表型，如通过PVT阳性患者中肿瘤多灶性和AFP水平的显著增加来判断的。除了MTD和AFP之外的因素也必须有助于PVT的发展。
Macroscopic portal vein invasion (PVT) by hepatocellular carcinoma (HCC) in the liver is one of the most important negative prognostic factors for HCC patients. The characteristics of a large cohort of such patients were examined. We found that the percent of patients with PVT significantly increased with increasing maximum tumor diameter (MTD), from 13.7% with tumors of MTD <5cm to 56.4% with tumors of MTD >10cm. There were similar numbers of HCC patients with very large tumors with and without PVT. Thus, MTD alone was insufficient to explain the presence of PVT, as were high AFP levels, since less than 50% of high AFP patients had PVT. However, the percent of patients with PVT was also found to significantly increase with increasing blood alpha-fetoprotein (AFP) levels and tumor multifocality. A logistic regression model that included these 3 factors together showed an odds ratio of 17.9 for the combination of MTD>5.0cm plus tumor multifocality plus elevated AFP, compared to low levels of these 3 parameters. The presence or absence of macroscopic PVT may therefore represent different HCC aggressiveness phenotypes, as judged by a significant increase in tumor multifocality and AFP levels in the PVT positive patients. Factors in addition to MTD and AFP must also contribute to PVT development.
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影响因子：
29.4
作者：
Roayaie S;Blume IN;Thung SN;Guido M;Fiel MI;Hiotis S;Labow DM;Llovet JM;Schwartz ME
通讯作者：
Schwartz ME
DOI：
10.1097/meg.0b013e3283535c34
发表时间：
2012-07-01
影响因子：
2.1
作者：
Kang, Se Hun;Kim, Do Young;Han, Kwang-Hyub
通讯作者：
Han, Kwang-Hyub
影响因子：
3.1
作者：
Carr, Brian I.;Wang, Ziqiu;Wei, Gang
通讯作者：
Wei, Gang
影响因子：
5
作者：
DODD, GD;CARR, BI
通讯作者：
CARR, BI
影响因子：
3.4
作者：
Kinoshita, Akiyoshi;Onoda, Hiroshi;Tajiri, Hisao
通讯作者：
Tajiri, Hisao