Log-transformed B-type natriuretic peptide as a prognostic predictor in patients undergoing cardiovascular surgery.
Log-transformed B-type natriuretic peptide as a prognostic predictor in patients undergoing cardiovascular surgery.
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DOI：
10.1177/0300060518809238
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Kanda T
中科院分区：
文献类型：
--
作者：
Takagi S;Machida Y;Kobata T;Sakamoto D;Sakamoto S;Kanda T
本研究旨在探讨接受心血管手术的患者中循环 B 型利钠肽 (BNP) 与其他死亡相关因素之间的关联。在这项观察性研究中，通过多水平线性回归分析和多水平生存分析，测量了 197 名患者 788 次重复数据测量中 4 个时间点的对数转换 BNP (lnBNP) 值。还研究了时间点和两个干预组（心脏手术和血管手术）之间相互作用的影响。评估了六个模型以确定最适合数据的模型。 Stata/MP® 14.2 版（Stata Corp.，College Station，TX，USA）用于分析两级方差分量模型拟合。 lnBNP的固定效应参数，如时间点、年龄、体重指数、急诊手术、预后营养指数、估计肾小球滤过率等存在显着差异。根据全因死亡和血管性死亡的多水平生存分析，lnBNP 存在显着差异，是常见的预后标志物。 lnBNP每增加1分，全因死亡增加2.07倍，血管性死亡增加3.10倍。 lnBNP 是接受心血管手术的患者的重要预后预测因子和定量生化标志物。
This study was performed to explore the association between circulating B-type natriuretic peptide (BNP) and other mortality-related factors in patients undergoing cardiovascular surgery. In this observational study, multilevel linear regression analysis and multilevel survival analysis were performed to measure the log-transformed BNP (lnBNP) value at four time points in 197 patients with 788 repeated data measurements. Effects of the interaction between the time points and the two intervention groups (cardiac surgery and vascular surgery) were also investigated. Six models were evaluated to identify the best fit for the data. Stata/MP® version 14.2 (Stata Corp., College Station, TX, USA) was used to analyze the two-level variance component model fitting. There were significant differences in the fixed-effect parameters of lnBNP, such as the time point, age, body mass index, emergency operation, prognostic nutritional index, and estimated glomerular filtration rate. According to the multilevel survival analysis for all-cause death and vascular death, lnBNP significantly differed and was a common prognostic marker. As lnBNP increased by 1 point, all-cause death increased 2.07 times and vascular death increased 3.10 times. lnBNP is an important prognostic predictor and quantitative biochemical marker in patients undergoing cardiovascular surgery.
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