Transforming Growth Factor‐β:A Promising Target for Anti‐Stenosis Therapy
Transforming Growth Factor‐β:A Promising Target for Anti‐Stenosis Therapy
复制标题
转化生长因子-β：抗狭窄治疗的一个有前景的靶点
DOI：
10.1111/j.1527-3466.2001.tb00074.x
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
J. Chamberlain
中科院分区：
文献类型：
--
作者：
J. Chamberlain
转化生长因子-β（TGF-β）是对生长和发育的许多方面具有广泛影响的细胞因子家族的总称。TGF-β同种型由大多数细胞类型产生，并通过与细胞表面上不同受体的相互作用以环境依赖性自分泌、旁分泌或内分泌方式发挥广泛的作用。TGF-β参与伤口愈合过程，因此在经皮腔内冠状动脉成形术（PTCA）或支架植入术后再狭窄病变的形成中起重要作用。也许是因为其广泛的影响，TGF-β通常以潜伏形式从细胞中释放，其激活和信号传导是复杂的。在动物模型中，通过抑制TGF-β 1、TGF-β 2和TGF-β 3亚型的表达、活化或信号传导来操纵它们可减少瘢痕形成和纤维化。然而，到目前为止，很少有临床试验。本文综述了TGF-β的激活和信号传导的最新研究进展，并重点介绍了抗TGF-β策略在预防PTCA或支架术后再狭窄中的临床应用。
Transforming growth factor-beta (TGF-beta) is the general name for a family of cytokines which have widespread effects on many aspects of growth and development. The TGF-beta isoforms are produced by most cell types and exert a wide range of effects in a context-dependent autocrine, paracrine or endocrine fashion via interactions with distinct receptors on the cell surface. TGF-beta is involved in the wound healing process and, thus plays a significant role in the formation of a restenotic lesion after percutaneous transluminal coronary angioplasty (PTCA) or stenting. Perhaps because of its wide-ranging effects, TGF-beta is usually released from cells in a latent form, and its activation and signaling are complex. Manipulation of the TGF-beta1, TGF-beta2, and TGF-beta3 isoforms by inhibiting their expression, activation, or signaling reduces scarring and fibrosis in animal models. However, to date, few have reached clinical trial. This review summarizes current knowledge on the activation and signaling of TGF-beta, and focuses on the anti-TGF-beta strategies which may lead to clinical applications in the prevention of restenosis following PTCA or stenting.
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影响因子：
15.9
作者：
WOLF, YG;RASMUSSEN, LM;RUOSLAHTI, E
通讯作者：
RUOSLAHTI, E
影响因子：
15.9
作者：
NIKOL, S;ISNER, JM;WEIR, L
通讯作者：
WEIR, L
影响因子：
37.8
作者：
Chen, DH;Asahara, T;Andrés, V
通讯作者：
Andrés, V
鼠腹膜巨噬细胞潜在 TGF-β 激活的表征。
DOI：
--
发表时间：
1995
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Nunes,I;Shapiro,RL;Rifkin,DB
通讯作者：
Rifkin,DB
DOI：
10.1073/pnas.88.2.580
发表时间：
1991-01-01
影响因子：
11.1
作者：
DENNIS, PA;RIFKIN, DB
通讯作者：
RIFKIN, DB