Mucin O-glycan branching enzymes: structure, function, and gene regulation.
Mucin O-glycan branching enzymes: structure, function, and gene regulation.
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DOI：
10.1007/978-1-4419-7877-6_25
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发表时间：
2011
影响因子：
--
通讯作者：
Radhakrishnan P
中科院分区：
文献类型：
--
作者：
Cheng PW;Radhakrishnan P
粘胶O-葡聚糖是共轭碳水化合物链，在还原末端含有N-乙酰半乳糖胺，与肽骨架中的丝氨酸/苏氨酸共价连接。它们存在于粘蛋白和许多非粘蛋白糖蛋白中。与粘蛋白O-葡聚糖高度糖基化的串联重复序列多肽的存在使粘蛋白有别于其他含有粘蛋白O-葡聚糖的糖蛋白。不含串联重复序列多肽的MUC14、-15和-18是例外。到目前为止，根据克隆的互补DNA序列[1，2]，已经报道了大约6种分泌型粘蛋白和14种膜系留粘蛋白。粘蛋白O-葡聚糖的功能因它们所处的位置而异。对于分泌的粘蛋白，O-葡聚糖可以保持水分，保持粘液分泌的粘弹性，并结合和清除吸入和摄入的病原体，如支原体[3，4]、病毒[5]和细菌[6]。这一功能主要依赖于非均相碳水化合物，而其他两种功能则由高碳水化合物含量决定。在分泌的粘蛋白中发现的高碳水化合物含量和非常不同的碳水化合物结构使它们能够在许多粘液分泌组织的上皮表面执行第一道天然免疫防御，如呼吸道和胃肠道。在病理条件下，分泌过多的粘蛋白加上粘液清除不良会导致阻塞性肺疾病[7]。
MucinO-glycans are conjugated carbohydrate chains that contain at the reducing terminusN-acetylgalactosamine linked covalently to serine/threonine in the peptide backbone. They are found in mucins and many nonmucin glycoproteins. The presence of a tandem repeat peptide heavily glycosylated with mucinO-glycans distinguishes mucins from other glycoproteins that contain mucinO-glycans. Muc14, -15, and -18, which do not contain a tandem repeat peptide, are the exceptions. To date, about six secreted and 14 membrane-tethered mucins have been reported based on cloned complementary DNA (cDNA) sequences [1, 2]. The functions of mucinO-glycans vary according to where they reside. For secreted mucins,O-glycans can retain water, maintain the viscoelastic properties of mucus secretion, and bind and clear inhaled and ingested pathogens, such as mycoplasma [3, 4], viruses [5], and bacteria [6]. This function depends primarily on heterogeneous carbohydrates, while the other two functions are determined by high carbohydrate content. High carbohydrate content and very heterogeneous carbohydrate structures found in secreted mucins enable them to perform the first line of innate immune defense at the epithelial surface of many mucus-secretory tissues, such as airways and the gastrointestinal tract. Under pathological conditions, overproduction of secreted mucins coupled with poor clearance of mucus causes obstructive lung diseases [7].
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DOI：
10.1165/rcmb.2003-0202oc
发表时间：
2004-05-01
影响因子：
6.4
作者：
Choi, KH;Osorio, FA;Cheng, PW
通讯作者：
Cheng, PW
影响因子：
15.3
作者：
Baum, Linda G.;Pang, Mabel;Perillo, Nancy L.;Wu, Terry;Delegeane, Angelo;Uittenbogaart, Christel H.;Fukuda, Minoru;Seilhamer, Jeffrey J.
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Seilhamer, Jeffrey J.
影响因子：
20.3
作者：
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通讯作者：
Baum, Linda G.
DOI：
10.1165/rcmb.2002-0147oc
发表时间：
2003-07-01
影响因子：
6.4
作者：
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通讯作者：
Cheng, PW
DOI：
10.1111/j.1432-1033.1986.tb09690.x
发表时间：
1986-06-16
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
BROCKHAUSEN, I;MATTA, KL;VANDENEIJNDEN, DH
通讯作者：
VANDENEIJNDEN, DH