Effect of spatial distribution of boron and oxygen concentration on DNA damage induced from boron neutron capture therapy using Monte Carlo simulations
Effect of spatial distribution of boron and oxygen concentration on DNA damage induced from boron neutron capture therapy using Monte Carlo simulations
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使用蒙特卡罗模拟，硼和氧浓度的空间分布对硼中子俘获疗法引起的 DNA 损伤的影响
DOI：
10.1080/09553002.2021.1928785
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发表时间：
2021-05
影响因子：
2.6
通讯作者：
Fada Guan
中科院分区：
文献类型：
--
作者：
Jie Qi;Changran Geng;Xiaobin Tang;Feng Tian;Yang Han;Huan Liu;Yuanhao Liu;Silva Bortolussi;Fada Guan
摘要目的利用Monte Carlo模拟方法研究硼中子俘获治疗（BNCT）中硼在细胞内的空间分布和氧浓度对荷电粒子诱导DNA损伤的影响，并进一步评价其诱导DNA双链断裂的相对生物学效应（RBE）。材料与方法从GEANT 4（Geant 4 10.05.p01）获得BNCT中α，7 Li粒子到达核表面的动能谱。然后使用MCDS（MCDS 3.10A）评估BNCT引起的DNA损伤。结果当α或7Li粒子分布于细胞膜或细胞质时，同种类型的DNA损伤差异小于0.5%。以137Cs光子为参考辐射，当氧浓度从0%变化到50%时，0.54MeV质子和反冲质子的相对能量比从5变化到2，而α或7Li粒子的相对能量比从10减小到3。结论BNCT中DSB诱导所有带电粒子的RBE随氧浓度的增加而降低。本研究表明，BNCT不同放射粒子的RBE可能受多种因素的影响，在理论研究或临床应用中应引起重视。
Abstract Purpose This paper aims to investigate how the spatial distribution of boron in cells and oxygen concentration affect the DNA damage induced by charged particles in boron neutron capture therapy (BNCT) by Monte Carlo simulations, and further to evaluate the relative biological effectiveness (RBE) of DNA double-strand breaks (DSBs) induction. Materials and methods The kinetic energy spectra of α, 7Li particles in BNCT arriving at the nucleus surface were obtained from GEANT4 (Geant4 10.05.p01). The DNA damage caused by BNCT was then evaluated using MCDS (MCDS 3.10A). Results When α or 7Li particles were distributed in the cytomembrane or cytoplasm, the difference in DNA damage of the same types was less than 0.5%. Taking the 137Cs photons as the reference radiation, when the oxygen concentration varied from 0% to 50%, the RBE of 0.54MeV protons and recoil protons varied from 5 to 2, whereas it decreased from 10 to 3 for α or 7Li particles. Conclusion The RBE of DSB induction all charged particles in BNCT decreased with the increase of oxygen concentration. This work indicated that the RBE of different radiation particles of BNCT might be affected by many factors, which should be paid attention to in theoretical research or clinical application.
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影响因子：
3.4
作者：
Hongyu Zhu;A. McNamara;S. McMahon;J. Ramos-Méndez;N. Henthorn;B. Faddegon;K. Held;J. Perl;Jun-Li Li-Jun-Li-Li-119581580;H. Paganetti;J. Schuemann
通讯作者：
Hongyu Zhu;A. McNamara;S. McMahon;J. Ramos-Méndez;N. Henthorn;B. Faddegon;K. Held;J. Perl;Jun-Li Li-Jun-Li-Li-119581580;H. Paganetti;J. Schuemann
影响因子：
--
作者：
Masunaga S;Sakurai Y;Tanaka H;Tano K;Suzuki M;Kondo N;Narabayashi M;Nakagawa Y;Watanabe T;Maruhashi A;Ono K
通讯作者：
Ono K
影响因子：
2
作者：
Okumura K;Kinashi Y;Kubota Y;Kitajima E;Okayasu R;Ono K;Takahashi S
通讯作者：
Takahashi S
影响因子：
3.5
作者：
Guan, Fada;Geng, Changran;Mohan, Radhe
通讯作者：
Mohan, Radhe
影响因子：
2.6
作者：
Rossini, Andres E.;Dagrosa, Maria A.;Pisarev, Mario A.
通讯作者：
Pisarev, Mario A.