RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells.
RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells.
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DOI：
10.1111/j.1749-6632.2010.05613.x
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发表时间：
2010-07
影响因子：
5.2
通讯作者：
St Clair WH
中科院分区：
文献类型：
--
作者：
Holley AK;Xu Y;St Clair DK;St Clair WH
放射治疗是治疗局限性前列腺癌的最前线。然而，相当大比例的患者患有耐辐射疾病。NF-κB通路是辐射抗性的重要因素，并且经典（规范）通路被认为赋予前列腺癌细胞免受电离辐射的保护。最近，参与前列腺癌侵袭性的替代（非经典）途径也被证明对前列腺癌的辐射抗性很重要。替代NF-κB途径组分RelB部分通过刺激位于前列腺的抗氧化酶锰超氧化物歧化酶（MnSOD）的表达来保护前列腺癌细胞免受电离辐射的有害影响。阻断RelB激活抑制MnSOD表达并使前列腺癌细胞对辐射敏感。这些结果表明，RelB介导的前列腺癌细胞的抗氧化能力的调制是辐射抗性的重要机制。因此，靶向RelB激活可能被证明是肿瘤学家武器库中击败侵袭性和耐辐射前列腺癌的有价值的武器。
Radiation therapy is in the front line for treatment of localized prostate cancer. However, a significant percentage of patients have radiation-resistant disease. The NF-κB pathway is an important factor for radiation resistance, and the classical (canonical) pathway is thought to confer protection of prostate cancer cells from ionizing radiation. Recently, the alternative (non-canonical) pathway, which is involved in prostate cancer aggressiveness, has also been shown to be important for radiation resistance in prostate cancer. The alternative NF-κB pathway component RelB protects prostate cancer cells from the detrimental effects of ionizing radiation, in part, by stimulating expression of the mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD). Blocking RelB activation suppresses MnSOD expression and sensitizes prostate cancer cells to radiation. These results suggest that RelB-mediated modulation of the antioxidant capacity of prostate cancer cells is an important mechanism of radiation resistance. Therefore, targeting RelB activation may prove to be a valuable weapon in the oncologist’s arsenal to defeat aggressive and radiation-resistant prostate cancer.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
DOI：
10.1084/jem.193.4.417
发表时间：
2001-02-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kaisho T;Takeda K;Tsujimura T;Kawai T;Nomura F;Terada N;Akira S
通讯作者：
Akira S
影响因子：
6
作者：
Felx, Melanie;Guyot, Marie-Claude;Moldovan, Florina
通讯作者：
Moldovan, Florina
影响因子：
4.4
作者：
Carragher, D;Johal, R;Caamaño, J
通讯作者：
Caamaño, J
影响因子：
5.3
作者：
Guo, GZ;Yan-Sanders, Y;Li, JJ
通讯作者：
Li, JJ