A pancancer analysis of the oncogenic role of ZNRF2 in human tumours.
A pancancer analysis of the oncogenic role of ZNRF2 in human tumours.
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ZNRF2在人类肿瘤中致癌作用的癌症分析。
DOI：
10.1111/jcmm.17900
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发表时间：
2023-11
影响因子：
5.3
通讯作者：
Sun, Xinlei
中科院分区：
文献类型：
--
作者：
Shi, Fujie;Wu, Yunfei;Wang, Kai;Wang, Jiafan;Liu, Minghui;Sun, Xinlei
寻找癌症的有效治疗方法需要彻底了解它是如何发展和进展的。最近的研究表明，锌和无名指2(ZNRF2)通过控制细胞生长和死亡在非小细胞肺癌(NSCLC)的进展中发挥关键作用。然而，对ZNRF2的S在整个癌症中的作用进行全面的分析还有待于进行。我们的研究试图利用TCGA(癌症基因组图谱)、GEO(基因表达总览)和人类蛋白质图谱(HPA)等数据库以及几种生物信息学工具来研究ZNRF2对各种人类肿瘤的影响以及涉及的分子通路。我们的研究结果表明，ZNRF2在肿瘤中的表达水平普遍高于正常组织，在某些癌症中，其水平与疾病分期呈正相关，可能预示着患者的预后不良。我们还发现了ZNRF2基因在癌症患者中的基因变化，以及它与癌症相关的成纤维细胞、内皮细胞和免疫细胞浸润的关系。此外，我们还探索了ZNRF2在肿瘤中的潜在分子机制，发现它在肝细胞癌组织中增加，并且通过ZNRF2 siRNA抑制其表达可以限制HepG2细胞的增殖。总体而言，我们的研究提供了ZNRF2的S在各种癌症中的致癌作用的全面概述。
Finding effective treatments for cancer requires a thorough understanding of how it develops and progresses. Recent research has revealed the crucial role that Zinc and ring finger 2 (ZNRF2) play in the progression of non‐small cell lung cancer (NSCLC) by controlling cell growth and death. However, a comprehensive analysis of ZNRF2's role in cancer as a whole has yet to be conducted. Our study sought to investigate the impact of ZNRF2 on diverse human tumours, as well as the molecular pathways involved, using databases such as TCGA (The Cancer Genome Atlas), GEO (Gene Expression Omnibus) and the Human Protein Atlas (HPA), as well as several bioinformatic tools. Our findings indicate that ZNRF2 is generally expressed at higher levels in tumours than in normal tissues, and in some cancers, its levels correlate positively with disease stage, potentially predicting a poor prognosis for patients. We also discovered genetic changes in ZNRF2 among cancer patients, as well as its relationship with cancer‐related fibroblasts, endothelial cells and immune cell infiltration. Additionally, we explored potential molecular mechanisms of ZNRF2 in tumours, finding that it increases in hepatocellular carcinoma (HCC) tissues and that inhibiting its expression through ZNRF2 siRNA can limit HepG2 cell proliferation. Overall, our study provides a comprehensive overview of ZNRF2's oncogenic roles across various cancers.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
7.7
作者：
Hoxhaj, Gerta D. K.;Caddye, Edward;MacKintosh, Carol
通讯作者：
MacKintosh, Carol
影响因子：
12.3
作者：
Li B;Severson E;Pignon JC;Zhao H;Li T;Novak J;Jiang P;Shen H;Aster JC;Rodig S;Signoretti S;Liu JS;Liu XS
通讯作者：
Liu XS
影响因子：
4.2
作者：
Li, Mao;Zhang, Shun;An, Ruifang
通讯作者：
An, Ruifang