Evaluation of the effect of dietary lycopene, the main carotenoid in tomato (Lycopersicon esculentum), on the in vivo renal reducing ability by a radiofrequency electron paramagnetic resonance method.
Evaluation of the effect of dietary lycopene, the main carotenoid in tomato (Lycopersicon esculentum), on the in vivo renal reducing ability by a radiofrequency electron paramagnetic resonance method.
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通过射频电子顺磁共振方法评价膳食番茄红素（番茄（Lycopersicon esculentum）中的主要类胡萝卜素）对体内肾功能降低能力的影响。
DOI：
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复制
发表时间：
2011
影响因子：
6.1
通讯作者：
T. Inakuma
中科院分区：
文献类型：
--
作者：
Kazutaka Yoshida;H. Yokoyama;T. Oteki;Gaku Matsumoto;K. Aizawa;T. Inakuma
虽然有报道称，番茄中主要的类胡萝卜素番茄红素可改善药物性肾病，但没有关于口服番茄红素对体内肾脏还原（即抗氧化）能力的影响的报道。射频电子顺磁共振（EPR）方法是一种独特的研究实验动物体内还原能力的技术。本研究采用配备表面线圈型谐振器的700 MHz EPR光谱仪，研究了口服番茄红素对大鼠肾脏还原能力的体内变化。老鼠被喂食对照饮食或含有番茄红素的饮食。2周后，进行体内EPR测量。番茄红素处理大鼠的肾衰能力明显高于对照组。这是首次通过膳食番茄红素增强体内抗氧化能力的验证。
Although it has been reported that dietary lycopene, the main carotenoid in tomato, improved drug-induced nephropathy, there are no reports on the effect of orally administered lycopene on the in vivo renal reducing (i.e., antioxidant) ability. The radiofrequency electron paramagnetic resonance (EPR) method is a unique technique by which the in vivo reducing ability of an experimental animal can be studied. In this study, the in vivo changes in the renal reducing ability of rats orally administered lycopene were investigated using a 700 MHz EPR spectrometer equipped with a surface-coil-type resonator. Rats were fed either a control diet or a diet containing lycopene. After 2 weeks, in vivo EPR measurements were conducted. The renal reducing ability of lycopene-treated rats was significantly greater than that of the control. This is the first verification of in vivo antioxidant enhancement via dietary lycopene administration.
化学产生的单线态氧对血浆和低密度脂蛋白成分的氧化。
DOI：
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发表时间：
1993
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Wagner,JR;Motchnik,PA;Stocker,R;Sies,H;Ames,BN
通讯作者：
Ames,BN
番茄红素可减弱表达 CYP2E1 的 HepG2 细胞的酒精性细胞凋亡。
DOI：
10.1016/s0006-291x(03)01435-9
发表时间：
2003
影响因子：
3.1
作者：
Xu,Youqing;Leo,MariaA;Lieber,CharlesS
通讯作者：
Lieber,CharlesS