Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients.
Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients.
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DOI：
10.1038/ki.2012.19
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发表时间：
2012-07
影响因子：
19.6
通讯作者：
中科院分区：
文献类型：
--
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先前的研究表明，关于终末期肾病中25-羟基维生素D（25（OH）D）水平与矿物质代谢之间的相关性，结果相互矛盾。为了确定生物可利用维生素D（未与维生素D结合蛋白结合的部分）与矿物质代谢指标的相关性是否比总水平更强，我们从一组血液透析患者中确定了94例先前测量25（OH）D和1，25-二羟基维生素D（1，25（OH）2D）的患者。维生素D结合蛋白从储存的血清样品中测定。使用先前验证的公式测定生物可利用的25（OH）D和1，25（OH）2D。研究了与人口统计学因素和矿物质代谢指标的关系。与白人相比，黑人患者的总25（OH）D水平较低，但不是生物可利用的。生物可利用的25（OH）D和1，25（OH）2D与血清钙显著相关，但与总的相关性不显著。在单变量和多变量回归分析中，只有生物可利用的25（OH）D与甲状旁腺激素水平显著相关。因此，在血液透析患者中，生物可利用维生素D水平与矿物质代谢指标的相关性优于总水平。
Prior studies showed conflicting results regarding the association between 25-hydroxyvitamin D (25(OH)D) levels and mineral metabolism in end-stage renal disease. In order to determine whether the bioavailable vitamin D (that fraction not bound to vitamin D binding protein) associates more strongly with measures of mineral metabolism than total levels, we identified 94 patients with previously measured 25(OH)D and 1,25-dihydroxyvitamin D (1,25(OH)2D) from a cohort of incident hemodialysis patients. Vitamin D binding protein was measured from stored serum samples. Bioavailable 25(OH)D and 1,25(OH)2D were determined using previously validated formulae. Associations with demographic factors and measures of mineral metabolism were examined. When compared with whites, black patients had lower levels of total, but not bioavailable, 25(OH)D. Bioavailable, but not total, 25(OH)D and 1,25(OH)2D were each significantly correlated with serum calcium. In univariate and multivariate regression analysis, only bioavailable 25(OH)D was significantly associated with parathyroid hormone levels. Hence, bioavailable vitamin D levels are better correlated with measures of mineral metabolism than total levels in patients on hemodialysis.
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影响因子：
4
作者：
Gutierrez, O. M.;Farwell, W. R.;Kermah, D.;Taylor, E. N.
通讯作者：
Taylor, E. N.
影响因子：
13.6
作者：
London, Gerard M.;Guerin, Alain P.;Metivier, Fabien
通讯作者：
Metivier, Fabien
DOI：
10.2215/cjn.06440909
发表时间：
2010-03-01
影响因子：
9.8
作者：
Bhan, Ishir;Burnett-Bowie, Sherri-Ann M.;Thadhani, Ravi
通讯作者：
Thadhani, Ravi
DOI：
10.1086/596314
发表时间：
2009-02-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Gombart AF;Bhan I;Borregaard N;Tamez H;Camargo CA Jr;Koeffler HP;Thadhani R
通讯作者：
Thadhani R
影响因子：
19.6
作者：
Chonchol, M.;Scragg, R.
通讯作者：
Scragg, R.