Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidation.
Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidation.
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DOI：
10.1186/s12906-016-1307-6
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发表时间：
2016-08-26
影响因子：
--
通讯作者：
Chae HJ
中科院分区：
文献类型：
--
作者：
Lee HY;Kim SW;Lee GH;Choi MK;Jung HW;Kim YJ;Kwon HJ;Chae HJ
姜黄素是姜黄的主要活性成分，以前曾报道过减轻肝损伤。在这里，我们研究了姜黄和姜黄素保护肝脏免受四氯化碳（CCl 4）诱导的大鼠损伤的机制。我们假设姜黄提取物和姜黄素通过减少氧化应激、抑制脂质过氧化和增加谷胱甘肽过氧化物酶活化来保护肝脏免受CCl 4诱导的肝损伤。慢性肝应激是通过单次腹腔注射四氯化碳（0.1毫升/公斤体重）到大鼠。姜黄提取物和姜黄素以三种剂量水平（100、200和300 mg/kg/天）每天给药一次，持续4周。我们进行了ALT和AST，还测量了总脂质、甘油三酯、胆固醇水平和脂质过氧化反应。我们发现，姜黄提取物和姜黄素显着防止肝损伤，通过降低血清天冬氨酸转氨酶和丙氨酸转氨酶的活动，并通过提高肝脏谷胱甘肽含量，导致脂质过氧化物酶水平降低。我们的数据表明，姜黄提取物和姜黄素通过抑制肝脏氧化应激保护肝脏免受慢性四氯化碳诱导的损伤。因此，姜黄提取物和姜黄素是用于治疗肝脏疾病的潜在治疗性抗氧化剂。本文的在线版本（doi：10.1186/s12906-016-1307-6）包含补充材料，可供授权用户使用。
Curcumin, a major active component of turmeric, has previously been reported to alleviate liver damage. Here, we investigated the mechanism by which turmeric and curcumin protect the liver against carbon tetrachloride (CCl4)-induced injury in rats. We hypothesized that turmeric extract and curcumin protect the liver from CCl4-induced liver injury by reducing oxidative stress, inhibiting lipid peroxidation, and increasing glutathione peroxidase activation. Chronic hepatic stress was induced by a single intraperitoneal injection of CCl4 (0.1 ml/kg body weight) into rats. Turmeric extracts and curcumin were administered once a day for 4 weeks at three dose levels (100, 200, and 300 mg/kg/day). We performed ALT and AST also measured of total lipid, triglyceride, cholesterol levels, and lipid peroxidation. We found that turmeric extract and curcumin significantly protect against liver injury by decreasing the activities of serum aspartate aminotransferase and alanine aminotransferase and by improving the hepatic glutathione content, leading to a reduced level of lipid peroxidase. Our data suggest that turmeric extract and curcumin protect the liver from chronic CCl4-induced injury in rats by suppressing hepatic oxidative stress. Therefore, turmeric extract and curcumin are potential therapeutic antioxidant agents for the treatment of hepatic disease. The online version of this article (doi:10.1186/s12906-016-1307-6) contains supplementary material, which is available to authorized users.
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影响因子：
4.2
作者：
Wu, GY;Fang, YZ;Turner, ND
通讯作者：
Turner, ND
影响因子：
4.3
作者：
Ma, Jie-Qiong;Ding, Jie;Liu, Chan-Min
通讯作者：
Liu, Chan-Min
DOI：
10.1007/bf01082441
发表时间：
1992-02-01
期刊：
HISTOCHEMICAL JOURNAL
影响因子：
--
作者：
JOHNSON, SJ;HINES, JE;BURT, AD
通讯作者：
BURT, AD
影响因子：
2.7
作者：
Savransky V;Reinke C;Jun J;Bevans-Fonti S;Nanayakkara A;Li J;Myers AC;Torbenson MS;Polotsky VY
通讯作者：
Polotsky VY
影响因子：
7.3
作者：
Punithavathi, D;Venkatesan, N;Babu, M
通讯作者：
Babu, M