Alcohol-focused and transdiagnostic treatments for unhealthy alcohol use among adults with HIV in Zambia: A 3-arm randomized controlled trial.
Alcohol-focused and transdiagnostic treatments for unhealthy alcohol use among adults with HIV in Zambia: A 3-arm randomized controlled trial.
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DOI：
10.1016/j.cct.2023.107116
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发表时间：
2023-04
影响因子：
2.2
通讯作者：
Kane, Jeremy C.
中科院分区：
文献类型：
--
作者：
Vinikoor, Michael J.;Sharma, Anjali;Murray, Laura K.;Figge, Caleb J.;Bosomprah, Samuel;Chitambi, Chipo;Paul, Ravi;Kanguya, Tukiya;Sivile, Suilanji;Nghiem, Van;Cropsey, Karen;Kane, Jeremy C.
人类免疫缺陷病毒 (PLWH) 感染者的临床和生活质量受到不健康饮酒 (UAU) 的影响，这种情况在该人群中非常普遍，并且往往因心理健康 (MH) 或其他物质使用 (SU) 合并症而变得复杂。在撒哈拉以南非洲地区，需要为艾滋病毒感染者和 UAU 患者提供循证且可实施的治疗方案。我们正在赞比亚卢萨卡的三个公共部门艾滋病毒诊所进行混合临床有效性实施试验。报告 UAU 且 HIV 临床结果欠佳的 HIV 感染者将被随机分配至三组之一：以酒精为重点的短期干预 (BI)、BI 并额外转诊至跨诊断认知行为疗法（通用要素治疗方法 [CETA]）或标准护理。 BI 和 CETA 将由 HIV 同伴咨询师提供，他们是赞比亚非专业卫生工作者的共同骨干。临床结果将包括 HIV 病毒抑制、酒精使用（通过音频计算机辅助自我访谈 (ACASI) 和直接酒精生物标志物、磷脂酰乙醇和乙基葡萄糖醛酸以及共病 MH 和其他 SU 进行评估）。还将分析一系列实施成果，包括成本效益。混合和三臂试验设计特点有助于对撒哈拉以南非洲 PLWH 中的 UAU 治疗方案进行综合评估，包括简短的、高度可实施的和更密集的、可实施性较差的治疗方案。 ACASI 和酒精生物标志物的使用将加强对治疗效果的了解。
Clinical and quality of life outcomes in people living with human immunodeficiency virus (PLWH) are undermined by unhealthy alcohol use (UAU), which is highly prevalent in this population and is often complicated by mental health (MH) or other substance use (SU) comorbidity. In sub-Saharan Africa, evidence-based and implementable treatment options for people with HIV and UAU are needed. We are conducting a hybrid clinical effectiveness-implementation trial at three public-sector HIV clinics in Lusaka, Zambia. Adults with HIV, who report UAU, and have suboptimal HIV clinical outcomes, will be randomized to one of three arms: an alcohol-focused brief intervention (BI), the BI with additional referral to a transdiagnostic cognitive behavioral therapy (Common Elements Treatment Approach [CETA]), or standard of care. The BI and CETA will be provided by HIV peer counselors, a common cadre of lay health worker in Zambia. Clinical outcomes will include HIV viral suppression, alcohol use, assessed by audio computer-assisted self-interview (ACASI) and direct alcohol biomarkers, Phophatidylethanol and Ethyl glucuronide, and comorbid MH and other SU. A range of implementation outcomes including cost effectiveness will also be analyzed. Hybrid and 3-arm trial design features facilitate the integrated evaluation of both brief, highly implementable, and more intensive, less implementable, treatment options for UAU among PLWH in sub-Saharan Africa. Use of ACASI and alcohol biomarkers will strengthen understanding of treatment effects.
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影响因子：
3.7
作者：
Gilbert, Paul;Ciccarone, Daniel;Gansky, Stuart A.;Bangsberg, David R.;Clanon, Kathleen;McPhee, Stephen J.;Calderon, Sophia H.;Bogetz, Alyssa;Gerbert, Barbara
通讯作者：
Gerbert, Barbara
影响因子：
3.7
作者：
in't Veld, Diana Huis;Ensoy-Musoro, Chellafe;Colebunders, Robert
通讯作者：
Colebunders, Robert
DOI：
10.1080/09540120500264134
发表时间：
2006-08-01
影响因子：
1.7
作者：
Aharonovich, E.;Hatzenbuehler, M. L.;Hasin, D. S.
通讯作者：
Hasin, D. S.
影响因子：
3.8
作者：
Langebeek, Nienke;Kooij, Katherine W.;Nieuwkerk, Pythia T.
通讯作者：
Nieuwkerk, Pythia T.
影响因子：
4.2
作者：
Inoue S;Chitambi C;Vinikoor MJ;Kanguya T;Murray LK;Sharma A;Chander G;Paul R;Mwenge MM;Munthali S;Kane JC
通讯作者：
Kane JC