Molecular and evolutionary processes generating variation in gene expression.
Molecular and evolutionary processes generating variation in gene expression.
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DOI：
10.1038/s41576-020-00304-w
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Wittkopp PJ
中科院分区：
文献类型：
--
作者：
Hill MS;Vande Zande P;Wittkopp PJ
基因表达的遗传变异在物种内部和物种之间是常见的。这种变异来自于改变分子基因调控网络的形式或功能的突变，然后通过自然选择进行过滤。引入突变并表征其对基因表达（特别是转录）的顺式和反式调节作用的高通量方法正在揭示不同的分子机制如何产生调节变异，而将这些突变效应与野生变异进行比较的研究正在区分中性和非中性进化过程的作用。这种分子生物学和进化生物学的整合使我们能够了解我们今天看到的基因表达的变化是如何形成的，并预测它在未来最有可能如何进化。
Heritable variation in gene expression is common within and between species. This variation arises from mutations that alter the form or function of molecular gene regulatory networks that are then filtered by natural selection. High-throughput methods for introducing mutations and characterizing their cis- and trans-regulatory effects on gene expression (particularly, transcription) are revealing how different molecular mechanisms generate regulatory variation, while studies comparing these mutational effects to variation seen in the wild are teasing apart the role of neutral and non-neutral evolutionary processes. This integration of molecular and evolutionary biology allows us to understand how the variation in gene expression we see today came to be and to predict how it is most likely to evolve in the future.
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遗传对人体组织基因表达的影响。
影响因子：
64.8
作者：
GTEx Consortium;Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group;Statistical Methods groups—Analysis Working Group;Enhancing GTEx (eGTEx) groups;NIH Common Fund;NIH/NCI;NIH/NHGRI;NIH/NIMH;NIH/NIDA;Biospecimen Collection Source Site—NDRI;Biospecimen Collection Source Site—RPCI;Biospecimen Core Resource—VARI;Brain Bank Repository—University of Miami Brain Endowment Bank;Leidos Biomedical—Project Management;ELSI Study;Genome Browser Data Integration &Visualization—EBI;Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz;Lead analysts:;Laboratory, Data Analysis &Coordinating Center (LDACC):;NIH program management:;Biospecimen collection:;Pathology:;eQTL manuscript working group:;Battle A;Brown CD;Engelhardt BE;Montgomery SB
通讯作者：
Montgomery SB
影响因子：
64.5
作者：
Boyle EA;Li YI;Pritchard JK
通讯作者：
Pritchard JK
影响因子：
7
作者：
Battle A;Mostafavi S;Zhu X;Potash JB;Weissman MM;McCormick C;Haudenschild CD;Beckman KB;Shi J;Mei R;Urban AE;Montgomery SB;Levinson DF;Koller D
通讯作者：
Koller D
影响因子：
9.8
作者：
Brynedal, Boel;Choi, JinMyung;Cotsapas, Chris
通讯作者：
Cotsapas, Chris
DOI：
10.1126/science.aax5217
发表时间：
2020-01-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Britton CS;Sorrells TR;Johnson AD
通讯作者：
Johnson AD