Moving in on human motor cortex. Characterizing the relationship between body parts with non-rigid population response fields.
Moving in on human motor cortex. Characterizing the relationship between body parts with non-rigid population response fields.
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DOI：
10.1371/journal.pcbi.1009955
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发表时间：
2022-04
影响因子：
4.3
通讯作者：
中科院分区：
文献类型：
--
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对于皮质运动活动，不同身体部位表征之间的关系是未知的。通过相互的身体部分的关系，功能的皮质运动区相对于全身运动控制的特点。在目前的研究中，我们调查的身体部位表示在运动皮层的单个神经元群体之间的关系，7特斯拉的功能磁共振成像18个身体部位的运动实验结合我们新开发的非刚性人口响应场（pRF）模型和图论。非刚性pRF指标揭示了所有包括的运动皮层中的躯体位置结构，包括额叶、顶叶、内侧和岛叶皮层，并且初级感觉运动皮层中的神经元群体比次级运动皮层响应更少的身体部位。互惠的身体部位关系的唯一性，形成的，和影响力方面进行了估计。我们报告了膝盖的独特反应，无名指周围的身体部位的一个集团，以及肩膀和手腕的核心作用。这些结果从中枢神经系统的角度揭示了身体部位之间的关联，同时与身体部位使用的直观概念一致。虽然超过一半的人类大脑在运动任务中表现出较高的活动水平，但仍然缺乏对皮质运动活动的完整理解。虽然感觉运动皮层的躯体组织已经被证明之前，躯体只是“冰山一角”的皮质运动活动。即使在初级感觉运动皮层，也有一小群神经元对身体多个部位的运动做出反应。这就提出了以下问题：不同身体部位的运动是如何在皮层反应轮廓中构造的，以及从人脑的角度来看，身体部位是如何相互关联的？在这里，我们调查的内在结构的小神经元群体在人类运动皮层后的18个身体部分的运动任务，使用我们新开发的非刚性群体响应场（pRF）的方法和高场功能磁共振成像。我们报告的躯体部位的结构，在所有的感觉运动皮层，和较小的反应领域的大小相比，次级运动皮层的初级感觉运动皮层。此外，我们表明，物理相邻的身体部位往往表示在对方的皮层反应领域。使用图论，我们揭示了皮质的身体部分表示之间的关系，如相对增加的影响，在任何18个运动条件下的神经元群体的肩膀和手腕。
For cortical motor activity, the relationships between different body part representations is unknown. Through reciprocal body part relationships, functionality of cortical motor areas with respect to whole body motor control can be characterized. In the current study, we investigate the relationship between body part representations within individual neuronal populations in motor cortices, following a 7 Tesla fMRI 18-body-part motor experiment in combination with our newly developed non-rigid population Response Field (pRF) model and graph theory. The non-rigid pRF metrics reveal somatotopic structures in all included motor cortices covering frontal, parietal, medial and insular cortices and that neuronal populations in primary sensorimotor cortex respond to fewer body parts than secondary motor cortices. Reciprocal body part relationships are estimated in terms of uniqueness, clique-formation, and influence. We report unique response profiles for the knee, a clique of body parts surrounding the ring finger, and a central role for the shoulder and wrist. These results reveal associations among body parts from the perspective of the central nervous system, while being in agreement with intuitive notions of body part usage. While over half the human brain shows elevated levels of activity during motor tasks, a complete understanding of cortical motor activity is still lacking. Although somatotopic organizations of sensorimotor cortices have been demonstrated before, a somatotopy is only the ‘tip of the iceberg’ for cortical motor activity. Small ensembles of neurons—even in primary sensorimotor cortex—respond to movements of multiple body parts. This raises the following questions: how are movements of different body parts structured within cortical response profiles, and how do body parts relate to each other from the human brain’s perspective? Here we investigate the intrinsic structure of small neuronal populations in human motor cortices following an 18-body-part motor task, using our newly developed non-rigid population Response Field (pRF) method and high-field functional MRI. We report somatotopic structures in all sensorimotor cortices, and smaller response field sizes in primary sensorimotor cortex compared to secondary motor cortices. Furthermore, we show that physically adjacent body parts are often represented in each other’s cortical response field. Using graph theory, we reveal relationships between cortical body part representations, such as the relatively increased influence of the shoulder and wrist within neuronal populations during any of the 18 motor conditions.
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影响因子：
5.7
作者：
Dounskaia N
通讯作者：
Dounskaia N
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