Pretreatment brain activation during stroop task is associated with outcomes in cocaine-dependent patients.
Pretreatment brain activation during stroop task is associated with outcomes in cocaine-dependent patients.
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DOI：
10.1016/j.biopsych.2008.05.024
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发表时间：
2008-12-01
影响因子：
10.6
通讯作者：
Potenza, Marc N.
中科院分区：
文献类型：
--
作者：
Brewer, Judson A.;Worhunsky, Patrick D.;Carroll, Kathleen M.;Rounsaville, Bruce J.;Potenza, Marc N.
可卡因依赖的认知行为和相关疗法可能会发挥其作用，部分是通过增强对药物使用行为的认知控制。没有以前的研究系统地检查了神经相关的认知控制与可卡因依赖的治疗结果。20名寻求治疗的可卡因依赖者在开始治疗前接受功能性磁共振成像（fMRI）时进行了Stroop任务。主要结果指标为可卡因阴性尿液药物筛查百分比、戒断天数百分比和治疗保留率。分析Stroop任务执行过程中区域脑激活与治疗结果测量之间的相关性。在Stroop表现过程中，个体激活了与非成瘾个体相似的大脑区域，包括前扣带皮层，背外侧前额叶皮层，顶叶小叶，纹状体和纹状体。治疗开始时的激活与特定结局差异相关：自我报告的戒断持续时间较长与腹内侧前额叶皮层、左后扣带皮层和右纹状体的激活相关，无药物尿液筛查百分比与纹状体激活相关，治疗保留与背外侧前额叶皮层的激活减少相关。Stroop效应和治疗保持率之间存在适度的相关性，认知控制相关的特定脑区的功能与可卡因依赖治疗的离散结果有差异。这些研究结果涉及神经回路的认知控制行为治疗的结果，并提供深入了解可卡因依赖的行为治疗的机制。他们还表明，在认知控制任务中的神经激活模式比行为测量更敏感地预测治疗反应。
Cognitive behavioral and related therapies for cocaine dependence may exert their effects, in part, by enhancing cognitive control over drug use behavior. No prior studies have systematically examined the neural correlates of cognitive control as related to treatment outcomes for cocaine dependence. Twenty treatment-seeking cocaine-dependent individuals performed a Stroop task while undergoing functional magnetic resonance imaging (fMRI) prior to initiating treatment. The primary outcome measures were percent of urine drug screens negative for cocaine, percent days abstinent, and treatment retention. Correlations between regional brain activation during Stroop task performance and treatment outcome measures were analyzed. During Stroop performance, individuals activated brain regions similar to those reported in non-addicted individuals, including the anterior cingulate cortex, dorsolateral prefrontal cortex, parietal lobule, insula and striatum. Activations at treatment onset correlated differentially with specific outcomes: longer duration of self-reported abstinence correlated with activation of ventromedial prefrontal cortex, left posterior cingulate cortex, and right striatum, percent drug-free urine screens correlated with striatal activation, and treatment retention correlated with diminished activation of dorsolateral prefrontal cortex. A modest correlation between Stroop effect and treatment retention was found. The functions of specific brain regions underlying cognitive control relate differentially to discrete outcomes for the treatment of cocaine dependence. These findings implicate neurocircuitry underlying cognitive control in behavioral treatment outcome and provide insight into the mechanisms of behavioral therapies for cocaine dependence. They also suggest neural activation patterns during cognitive control tasks are more sensitive predictors of treatment response than behavioral measures.
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DOI：
10.1073/pnas.111134598
发表时间：
2001-06-05
影响因子：
11.1
作者：
Egan, MF;Goldberg, TE;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
--
作者：
Blumberg, HP;Leung, HC;Peterson, BS
通讯作者：
Peterson, BS
影响因子：
7.6
作者：
Kosten, TR;Scanley, BE;Wexler, BE
通讯作者：
Wexler, BE
影响因子：
17.7
作者：
Marsh, Rachel;Zhu, Hongtu;Peterson, Bradley S.
通讯作者：
Peterson, Bradley S.
影响因子：
64.8
作者：
Montague, PR;Hyman, SE;Cohen, JD
通讯作者：
Cohen, JD