The effects of continuous cocaine duration on the induction of behavioral tolerance and dopamine autoreceptor function.
The effects of continuous cocaine duration on the induction of behavioral tolerance and dopamine autoreceptor function.
复制标题
连续可卡因持续时间对诱导行为耐受性和多巴胺自身受体功能的影响。
DOI：
10.1016/s0014-2999(02)01822-8
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发表时间：
2002
影响因子：
5
通讯作者：
Castro,Gene
中科院分区：
文献类型：
--
作者：
King,GeorgeR;Pinto,Gail;Konen,Jennifer;Hillburn,Craig;Tran,Sophie;Love,Wees;Cayse,Rachel;Castro,Gene
The current experiment evaluated the duration-dependent nature of the induction of behavioral tolerance and changes in dopamine autoreceptor function by continuously administering cocaine for different durations. For all experiments, rats were exposed to a pretreatment regimen involving the continuous administration of 40 mg/kg/day cocaine. The pretreatment regimen lasted 3, 7, or 14 days. All subjects were then withdrawn from the pretreatment regimen for 7 days. The subjects were placed in activity monitors and ambulation measured. In experiment 1, the subjects were challenged with 0.0, 7.5, or 15.0 mg/kg i.p. cocaine on day 7 of withdrawal from the continuous cocaine administration regimen. The results indicated that all continuous cocaine durations induced significant tolerance to the 7.5 and 15.0 mg/kg cocaine challenge, relative to the control group. However, the magnitude of tolerance was not duration dependent. In experiment 2, the subjects were challenged with 0.063 or 0.125 mg/kg quinpirole. The results indicated that the 0.063 mg/kg quinpirole challenge inhibited activity in both pretreatment groups, while the 0.125 mg/kg quinpirole challenge enhanced behavior in the saline control, but not the cocaine, pretreatment group. In experiment 3, the subjects were challenged with the same doses of quinpirole in combination with 7.5 mg/kg i.p. cocaine. Both quinpirole challenge doses inhibited cocaine-induced hyperactivity. The results suggest that the induction of tolerance by continuous cocaine administration is not duration-dependent. Continuous cocaine administration did induce dopamine autoreceptor supersensitivity. Different continuous cocaine durations may induce differential degrees of dopamine autoreceptor supersensitivity.
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影响因子：
5
作者：
TRICKLEBANK, MD;SINGH, L;IVERSEN, SD
通讯作者：
IVERSEN, SD
连续可卡因和安非他明对缰核的神经毒性作用：对精神病基质的影响。
DOI：
--
发表时间：
1996
期刊：
NIDA research monograph
影响因子：
--
作者：
G. Ellison;S. Irwin;A. Keys;K. Noguchi;G. Sulur
通讯作者：
G. Sulur
影响因子：
3.9
作者：
DACKIS C A;GOLD M S
通讯作者：
GOLD M S
自由活动大鼠内侧前额皮质中 5-HT3 受体激活可增强突触前多巴胺释放
影响因子：
2.3
作者：
Jianping Chen;W. Paredes;H. M. van Praag;J. Lowinson;E. Gardner
通讯作者：
E. Gardner
戒断连续或间歇性可卡因给药：D2 受体功能的变化。
DOI：
--
发表时间：
1994
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
King,GR;EllinwoodJr,EH;Silvia,C;Joyner,CM;Xue,Z;Caron,MG;Lee,TH
通讯作者：
Lee,TH