Correlates of Stimulus-Response Congruence in the Posterior Parietal Cortex

Correlates of Stimulus-Response Congruence in the Posterior Parietal Cortex
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后顶叶皮层刺激反应一致性的相关性

DOI:
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发表时间:
2007
影响因子:
3.2
通讯作者:
L. Snyder
L. Snyder
中科院分区:
医学3区
文献类型:
--
作者:
G. Stoet;L. Snyder

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灵长类动物的行为是灵活的:对刺激的反应往往取决于它发生的任务。在这里,我们研究了后顶叶皮层(PPC)的单个神经元如何对刺激做出反应,这些刺激与不同任务中的不同反应相关。两只恒河猴进行了一次任务转换实验。每次试验都以任务提示开始,指示执行两项任务中的哪一项,然后是需要按下左或右按钮的刺激。对于一半的刺激,相关的反应是不同的,在两个任务,这意味着任务的上下文是必要的,以消除歧义的不一致的刺激。另一半的刺激需要相同的反应,无论任务上下文(一致)。使用这种模式,我们以前表明,行为反应不一致的刺激是显着慢于一致的刺激。我们现在证明了PPC中的神经相关性,即不一致刺激所需的额外处理时间。此外,我们之前发现29%的顶叶神经元编码正在执行的任务(任务选择细胞)。我们现在报告的差异,在任务选择性与任务非选择性细胞的一致性相关的神经元计时。这些时间上的差异表明,任务非选择性细胞的活动反映了运动指令,而任务选择性细胞的活动反映了决策过程。
Primate behavior is flexible: The response to a stimulus often depends on the task in which it occurs. Here we study how single neurons in the posterior parietal cortex (PPC) respond to stimuli which are associated with different responses in different tasks. Two rhesus monkeys performed a task-switching paradigm. Each trial started with a task cue instructing which of two tasks to perform, followed by a stimulus requiring a left or right button press. For half the stimuli, the associated responses were different in the two tasks, meaning that the task context was necessary to disambiguate the incongruent stimuli. The other half of stimuli required the same response irrespective of task context (congruent). Using this paradigm, we previously showed that behavioral responses to incongruent stimuli are significantly slower than to congruent stimuli. We now demonstrate a neural correlate in the PPC of the additional processing time required for incongruent stimuli. Furthermore, we previously found that 29% of parietal neurons encode the task being performed (task-selective cells). We now report differences in neuronal timing related to congruency in task-selective versus task nonselective cells. These differences in timing suggest that the activity in task nonselective cells reflects a motor command, whereas activity in task-selective cells reflects a decision process.
DOI: 10.1093/cercor/10.6.552
发表时间: 2000-06-01
期刊: CEREBRAL CORTEX
影响因子: 3.7
作者:
Leung, HC;Skudlarski, P;Gore, JC
通讯作者: Gore, JC
DOI: 10.1126/science.4048942
发表时间: 1985-01-01
期刊: SCIENCE
影响因子: 56.9
作者:
ANDERSEN, RA;ESSICK, GK;SIEGEL, RM
通讯作者: SIEGEL, RM
DOI: 10.1073/pnas.87.1.256
发表时间: 1990-01-01
影响因子: 11.1
作者:
PARDO, JV;PARDO, PJ;RAICHLE, ME
通讯作者: RAICHLE, ME