Elevated IP-10 and IL-6 from bronchoalveolar lavage cells are biomarkers of non-cavitary tuberculosis.
Elevated IP-10 and IL-6 from bronchoalveolar lavage cells are biomarkers of non-cavitary tuberculosis.
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DOI：
10.5588/ijtld.12.0610
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发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
Weiden MD
中科院分区：
文献类型：
--
作者：
Nolan A;Condos R;Huie ML;Dawson R;Dheda K;Bateman E;Rom WN;Weiden MD
结核病每年在全球造成近150万人死亡。活动性肺结核可以破坏肺实质，导致龋齿。在结核病期间，使个人免受肺损伤的免疫反应并不明确。受试者(N=73)有双侧肺浸润物，并接受了支气管肺泡灌洗(BAL)，以采集肺免疫细胞并测定BAL细胞因子的产生。所有患者均有痰培养显示结核分枝杆菌，其中22/73(30%)胸片上有空洞。与不存在空洞的患者相比，出现空洞的患者BAL中中性粒细胞百分比较高，而BAL细胞培养上清液中IP-10和IL-6的比例较低(p=0.013)。空洞与其他BAL或血清细胞因子无相关性。IP-10与BAL PMN呈负相关。在Logistic回归模型中，中位数以上的IP-10和IL-6的表达使龋齿的风险分别降低了79%和78%。主成分分析显示，IL-10、IL-6与干扰素-γ、肿瘤坏死因子-α聚为一类，IL-4与中性粒细胞聚为一类。BAL细胞产生的IP-10和IL-6的增加与放射学晚期结核病患者的非空洞性结核病有关。IP-10和IL-6可能反映了一条有效的Th-1免疫控制途径，减轻了肺结核对肺的破坏。
Tuberculosis (TB) causes nearly 1.5 million deaths annually worldwide. Active TB disease can destroy lung parenchyma leading to cavities. Immune responses that predispose or protect individuals from lung damage during tuberculosis are poorly defined. Enrolled subjects (N=73) had bilateral infiltrates and underwent bronchoalveolar lavage (BAL) to sample lung immune cells and assay BAL cell cytokine production. All had sputum culture demonstrating Mycobacterium tuberculosis and 22/73 (30%) had cavities on their chest radiograph. Those with cavities at presentation had higher percent PMN in BAL as well as lower IP-10 (p<0.01) and IL-6 (p=0.013) in BAL cell supernatants, compared to those without cavities. There was no correlation between cavities and other BAL or serum cytokines. IP-10 was negatively associated with BAL PMN. IP-10 and IL-6 expression above median decrease the odds of cavities by 79% and 78% in logistic regression models. IP-10 and IL-6 clustered with IFN-γ and TNF-α in a principal component analysis while IL-4 clustered with PMN. Increasing IP-10 and IL-6 production by BAL cells is associated with non-cavitary tuberculosis in patients who present with radiographically advanced TB. IP-10 and IL-6 may reflect an effective Th-1 immune control pathway for TB, attenuating tuberculous lung destruction.
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DOI：
10.1165/ajrcmb.24.2.4274
发表时间：
2001-02-01
影响因子：
6.4
作者：
Marchant, A;Amedei, A;Del Prete, G
通讯作者：
Del Prete, G
影响因子：
10
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影响因子：
4.6
作者：
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通讯作者：
Sanduzzi, A
影响因子：
3.1
作者：
Raju, B;Hoshino, Y;Weiden, MD
通讯作者：
Weiden, MD
DOI：
10.1084/jem.20052545
发表时间：
2006-07-10
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Khader SA;Partida-Sanchez S;Bell G;Jelley-Gibbs DM;Swain S;Pearl JE;Ghilardi N;Desauvage FJ;Lund FE;Cooper AM
通讯作者：
Cooper AM