Clostridium difficile isolates with increased sporulation: emergence of PCR ribotype 002 in Hong Kong.
Clostridium difficile isolates with increased sporulation: emergence of PCR ribotype 002 in Hong Kong.
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DOI：
10.1007/s10096-011-1231-0
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发表时间：
2011-11
影响因子：
4.5
通讯作者：
Yuen, K. Y.
中科院分区：
文献类型：
--
作者：
Cheng, V. C. C.;Yam, W. C.;Lam, O. T. C.;Tsang, J. L. Y.;Tse, E. Y. F.;Siu, G. K. H.;Chan, J. F. W.;Tse, H.;To, K. K. W.;Tai, J. W. M.;Ho, P. L.;Yuen, K. Y.
我们鉴定了艰难梭菌 PCR 核糖型 002 的主要克隆，该克隆与孢子形成频率增加相关。 2009 年，香港一个医疗保健区对来自 2,440 名患者的 3,528 份粪便样本进行了产毒艰难梭菌检测。共发现来自 307 名（13.3%）患者的 345 种产毒菌株。核糖型 002 是主要的核糖型，由来自 29 名 (9.4%) 患者的 35 个样本组成。核糖核酸型002的平均孢子形成频率为20.2%，显着高于随机选择的除002之外的56个核糖核酸作为同期对照（3.7%，p<0.001）。与对照组相比，携带产毒核糖核酸型 002 的患者更频繁地从老人院入院 (p = 0.01)，并且在前 3 个月内接受了更多的 β-内酰胺抗生素 (p = 0.04)。 2009 年产毒核糖核酸型 002 的鉴定与第一阶段期间产毒艰难梭菌发病率从每 1,000 名入院者 0.53 例显着增加至 0.95 例（p < 0.001）以及阳性检测率从 4.17% 显着增加至 6.28%（p < 0.001）有关。 （2004-2008 年）和第 2 期（2009 年）。这一发现应该提醒医生和感染控制团队注意我们医院中核糖核酸型 002 的建立和可能的爆发，就像核糖核酸型 027 的情况一样。
We identified a predominant clone of Clostridium difficile PCR ribotype 002, which was associated with an increased sporulation frequency. In 2009, 3,528 stool samples from 2,440 patients were tested for toxigenic C. difficile in a healthcare region in Hong Kong. A total of 345 toxigenic strains from 307 (13.3%) patients were found. Ribotype 002 was the predominant ribotype, which constituted 35 samples from 29 (9.4%) patients. The mean sporulation frequency of ribotype 002 was 20.2%, which was significantly higher than that of the 56 randomly selected ribotypes other than 002 as concurrent controls (3.7%, p < 0.001). Patients carrying toxigenic ribotype 002 were more frequently admitted from an elderly home (p = 0.01) and received more β-lactam antibiotics in the preceding 3 months compared with the controls (p = 0.04) . The identification of toxigenic ribotype 002 in 2009 was temporally related to a significant increase in both the incidence of toxigenic C. difficile from 0.53 to 0.95 per 1,000 admissions (p < 0.001) and the rate of positive detection from 4.17% to 6.28% (p < 0.001) between period 1 (2004–2008) and period 2 (2009). This finding should alert both the physician and the infection control team to the establishment of and possible outbreaks by ribotype 002 in our hospitals, as in the case of ribotype 027.
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影响因子：
9.4
作者：
Fawley, WN;Parnell, P;Wilcox, MH
通讯作者：
Wilcox, MH
影响因子：
4.5
作者：
Jabbar, Umair;Leischner, Julie;Gerding, Dale N.
通讯作者：
Gerding, Dale N.
影响因子：
4.5
作者：
Fawley, Warren N.;Underwood, Sarah;Wilcox, Mark H.
通讯作者：
Wilcox, Mark H.
DOI：
10.1016/s0924-8579(09)70009-3
发表时间：
2009-03-01
影响因子：
10.8
作者：
Coia, John E.
通讯作者：
Coia, John E.
影响因子：
4.9
作者：
DZINK, J;BARTLETT, JG
通讯作者：
BARTLETT, JG