Light regulates alternative splicing outcomes via the TOR kinase pathway.
Light regulates alternative splicing outcomes via the TOR kinase pathway.
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DOI：
10.1016/j.celrep.2021.109676
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发表时间：
2021-09-07
期刊：
影响因子：
8.8
通讯作者：
Petrillo E
中科院分区：
文献类型：
--
作者：
Riegler S;Servi L;Scarpin MR;Godoy Herz MA;Kubaczka MG;Venhuizen P;Meyer C;Brunkard JO;Kalyna M;Barta A;Petrillo E
对于植物而言，光是能量的来源，也是生长以及通过诱导包括可变剪接在内的不同层面基因表达变化来实现环境适应性的最关键调节因子。光触发的叶绿体逆向信号调控拟南芥中的可变剪接。在此，我们提供证据表明光调控根中一组核心剪接相关因子的表达。根中的可变剪接反应并非直接由光引起，而更有可能是由光合作用产生的糖类所触发。雷帕霉素靶蛋白（TOR）激酶在这种从地上部分到根的信号通路中起着关键作用。敲低TOR表达或通过药物抑制TOR活性，会破坏根中对光和外源糖类的可变剪接反应。同样地，根中的剪接决策受线粒体活动的调节。总之，糖类通过激活TOR通路，作为可移动信号来协调整株植物对光的可变剪接反应。
里格勒等人揭示了TOR激酶与逆向信号传导在根以及在一定程度上在叶中光调控可变剪接过程中的核心作用。糖类通过激活TOR通路，作为可移动信号来协调整株植物对光的可变剪接反应。
For plants, light is the source of energy and the most relevant regulator of growth and adaptations to the environment by inducing changes in gene expression at various levels, including alternative splicing. Light-triggered chloroplast retrograde signals control alternative splicing in Arabidopsis thaliana. Here, we provide evidence that light regulates the expression of a core set of splicing-related factors in roots. Alternative splicing responses in roots are not directly caused by light but are instead most likely triggered by photo-synthesized sugars. The target of rapamycin (TOR) kinase plays a key role in this shoot-to-root signaling pathway. Knocking down TOR expression or pharmacologically inhibiting TOR activity disrupts the alternative splicing responses to light and exogenous sugars in roots. Consistently, splicing decisions are modulated by mitochondrial activity in roots. In conclusion, by activating the TOR pathway, sugars act as mobile signals to coordinate alternative splicing responses to light throughout the whole plant. Riegler et al. reveal a central role for TOR kinase paired with retrograde signaling in alternative splicing regulation by light in roots and, to a certain extent, in leaves. Activating the TOR pathway, sugars act as mobile signals to coordinate alternative splicing responses to light throughout the whole plant.
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