Increased lipoxygenase and decreased cytochrome P450s metabolites correlated with the incidence of diabetic nephropathy: Potential role of eicosanoids from metabolomics in type 2 diabetic patients

Increased lipoxygenase and decreased cytochrome P450s metabolites correlated with the incidence of diabetic nephropathy: Potential role of eicosanoids from metabolomics in type 2 diabetic patients
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脂氧合酶增加和细胞色素 P450s 代谢物减少与糖尿病肾病的发病率相关:代谢组学中类二十烷酸在 2 型糖尿病患者中的潜在作用

DOI:
10.1111/1440-1681.13471
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发表时间:
2021-02
影响因子:
2.9
通讯作者:
Wang Gang
Wang Gang
中科院分区:
医学4区
文献类型:
--
作者:
Peng Liyuan;Sun Bei;Liu Yajin;Huang Jing;Chen Guangzhi;Zhang Xu;Chen Chen;Wang Daowen;Wang Gang

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糖尿病肾病(DN)是慢性肾病和终末期肾病的主要病因。先前的研究表明,长链omega - 3多不饱和脂肪酸(PUFAs)可能具有减少DN患者蛋白尿的治疗潜力
Diabetic nephropathy (DN) is the major cause of chronic kidney disease and end‐stage renal disease. Previous studies have demonstrated that longchain omega3 polyunsaturated fatty acids (PUFAs) might have therapeutic potential in reducing proteinuria in DN
细胞色素 P450 环氧化酶 CYP2J2 可减轻链脲佐菌素诱导的糖尿病小鼠的肾病。
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