IRBIT: it is everywhere.
IRBIT: it is everywhere.
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DOI:
10.1007/s11064-010-0353-6
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发表时间:
2011-07
影响因子:
4.4
通讯作者:
Muallem, Shmuel
中科院分区:
文献类型:
--
作者:
Yang, Dongki;Shcheynikov, Nikolay;Muallem, Shmuel
IRBIT (IP3Rs binding protein released with IP3) is a protein originally identified by the Mikoshiba group as an inhibitor of IP3 receptors function. Subsequently it was found to have multiple functions and regulate the activity of diverse proteins, including regulation of HCO2− transporters to coordinate epithelial HCO3− secretion and to determine localization of the Fip1 subunit of the CPSF complex to regulate mRNA processing. This review highlights the remarkably divers functions of IRBIT that are likely only a fraction of all the potential functions of this protein.
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