IRBIT: it is everywhere.

IRBIT: it is everywhere.
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DOI:
10.1007/s11064-010-0353-6
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发表时间:
2011-07
影响因子:
4.4
通讯作者:
Muallem, Shmuel
Muallem, Shmuel
中科院分区:
医学3区
文献类型:
--
作者:
Yang, Dongki;Shcheynikov, Nikolay;Muallem, Shmuel

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IRBIT(与IP3一起释放的IP3受体结合蛋白)是一种最初由Mikoshiba团队鉴定为IP3受体功能抑制剂的蛋白质。随后发现它具有多种功能,并调节多种蛋白质的活性,包括调节碳酸氢根离子转运蛋白以协调上皮细胞碳酸氢根离子的分泌,以及确定剪切和多聚腺苷酸化特异性因子(CPSF)复合物的Fip1亚基的定位以调节信使核糖核酸(mRNA)的加工。这篇综述强调了IRBIT极其多样的功能,而这些功能可能只是这种蛋白质所有潜在功能的一小部分。
IRBIT (IP3Rs binding protein released with IP3) is a protein originally identified by the Mikoshiba group as an inhibitor of IP3 receptors function. Subsequently it was found to have multiple functions and regulate the activity of diverse proteins, including regulation of HCO2− transporters to coordinate epithelial HCO3− secretion and to determine localization of the Fip1 subunit of the CPSF complex to regulate mRNA processing. This review highlights the remarkably divers functions of IRBIT that are likely only a fraction of all the potential functions of this protein.
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