Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies.
Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies.
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DOI：
10.1016/j.canlet.2014.08.003
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发表时间：
2014-11-01
期刊：
影响因子：
9.7
通讯作者：
Zhou, Jia
中科院分区：
文献类型：
--
作者：
Chen, Haijun;Gao, Yu;Wu, Jianlei;Chen, Yingyu;Chen, Buyuan;Hu, Jianda;Zhou, Jia
尽管在针对各种类型的恶性血液病的靶向治疗方面取得了巨大进展，成功地提高了生存率，但新出现的耐药问题却高得惊人，迫切需要新的治疗策略。此外，化学预防目前正在成为一个难以捉摸的目标。近年来，植物源性天然产物由于具有潜在的化疗和膳食化学预防双重功能而受到广泛关注。其中一个特别普遍的家庭是多酚类黄酮。其中黄芩苷及其苷元黄芩素因具有显著的药理作用而在血液系统恶性肿瘤中得到广泛研究。本文综述了近年来黄芩苷和黄芩素在恶性血液病治疗中的研究进展。这两种黄酮类化合物靶向不同的信号通路和它们在不同类型的血液恶性肿瘤中的潜在生物学机制的有前途的抗癌活性，以及与黄芩苷或黄芩素的组合策略作为这些难治性疾病的最近疗法的化疗佐剂进行了讨论。同时，对黄芩苷和黄芩素的生物转化及提高其生物利用度的途径进行了综述。
Despite tremendous advances in the targeted therapy for various types of hematological malignancies with successful improvements in the survival rates, emerging resistance issues are startlingly high and novel therapeutic strategies are urgently needed. In addition, chemoprevention is currently becoming an elusive goal. Plant-derived natural products have garnered considerable attention in recent years due to the potential dual functions as chemotherapeutics and dietary chemoprevention. One of the particularly ubiquitous families is the polyphenolic flavonoids. Among them, baicalin and its aglycone baicalein have been widely investigated in hematological malignancies because both of them exhibit remarkable pharmacological properties. This review focuses on the recent achievements in drug discovery research associated with baicalin and baicalein for hematological malignancy therapies. The promising anticancer activities of these two flavonoids targeting diverse signaling pathways and their potential biological mechanisms in different types of hematological malignancies, as well as the combination strategy with baicalin or baicalein as chemotherapeutic adjuvants for recent therapies in these intractable diseases are discussed. Meanwhile, the biotransformation of baicalin and baicalein and the relevant approaches to improve their bioavailability are also summarized.
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DOI：
10.4137/cmo.s8014
发表时间：
2013-08-19
期刊：
Clinical Medicine Insights. Oncology
影响因子：
--
作者：
Castelli R;Gualtierotti R;Orofino N;Losurdo A;Gandolfi S;Cugno M
通讯作者：
Cugno M
影响因子：
6.1
作者：
Li Qiu-Bai;You Yong;Zou Ping
通讯作者：
Zou Ping
DOI：
10.1186/1756-9966-31-48
发表时间：
2012-05-20
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Huang Y;Hu J;Zheng J;Li J;Wei T;Zheng Z;Chen Y
通讯作者：
Chen Y
影响因子：
2.8
作者：
Ikezoe, T;Chen, SS;Koeffler, HP
通讯作者：
Koeffler, HP
影响因子：
3.2
作者：
Ding, Derong;Zhang, Baozi;Shen, Jingkang
通讯作者：
Shen, Jingkang