Mitochondrial oxidative damage and apoptosis in age-related hearing loss.
Mitochondrial oxidative damage and apoptosis in age-related hearing loss.
复制标题
DOI：
10.1016/j.mad.2010.04.006
复制
发表时间：
2010-07
影响因子：
5.3
通讯作者：
Prolla, Tomas A.
中科院分区：
文献类型：
--
作者：
Someya, Shinichi;Prolla, Tomas A.
关键词：
Age-related hearing loss (AHL) is a universal feature of mammalian aging and is the most common sensory disorder in the elderly population. Experimental evidence suggests that mitochondrial dysfunction associated with reactive oxygen species (ROS) plays a central role in the aging process of cochlear cells. Although it is well established that mitochondria are the major source of ROS in the cell, specific molecular mechanisms of aging induced by ROS remain poorly characterized. Here we review the evidence that supports a central role for Bak-mediated mitochondrial apoptosis in AHL. We also propose that this mechanism may be of general relevance to age-related cell death in long-lived post-mitotic cells of multiple tissues, providing an opportunity for a targeted therapeutic intervention in human aging.
登录
查看更多内容
影响因子：
1.7
作者：
Ahn, Joong Ho;Kang, Hun Hee;Chung, Jong Woo
通讯作者：
Chung, Jong Woo
影响因子：
10.5
作者：
Chen, Yi-Fan;Kao, Cheng-Heng;Tsai, Ting-Fen
通讯作者：
Tsai, Ting-Fen
影响因子：
9.9
作者：
Crimi, M;Galbiati, S;Comi, GP
通讯作者：
Comi, GP
影响因子：
--
作者：
Filosto, M;Mancuso, M;DiMauro, S
通讯作者：
DiMauro, S
影响因子：
14.5
作者：
Hudson, Gavin;Amati-Bonneau, Patrizia;Taylor, Robert W.
通讯作者：
Taylor, Robert W.