Towards robust and replicable sex differences in the intrinsic brain function of autism.
Towards robust and replicable sex differences in the intrinsic brain function of autism.
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在自闭症的内在脑功能上的强大和可复制的性别差异。
DOI：
10.1186/s13229-021-00415-z
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发表时间：
2021-03-01
期刊：
影响因子：
6.2
通讯作者：
Di Martino A
中科院分区：
文献类型：
--
作者：
Floris DL;Filho JOA;Lai MC;Giavasis S;Oldehinkel M;Mennes M;Charman T;Tillmann J;Dumas G;Ecker C;Dell'Acqua F;Banaschewski T;Moessnang C;Baron-Cohen S;Durston S;Loth E;Murphy DGM;Buitelaar JK;Beckmann CF;Milham MP;Di Martino A
自闭症患病率的显著性别差异突出了了解生物性相关因素在自闭症中的作用的必要性。然而，解开自闭症大脑组织中的性别差异的努力受到了女性数据有限的挑战。我们通过使用患有自闭症的男性和女性以及神经典型(NT)对照组的大样本来解决这一差距(自闭症：362名男性，82名女性；NT：409名男性，166名女性；7-18岁)。发现分析研究了五个静态功能磁共振成像(R-fMRI)指标(体素级Z >； 3.1，簇级P <； 0.01，高斯随机场校正)的诊断、性别及其相互作用的主要影响。二次分析评估了结果对不同前处理方法的稳健性及其在两个独立样本中的可重复性：欧盟-AIMS欧洲自闭症纵向项目(LEAP)和促进自闭症研究的神经遗传学和发育的性别探索。在《观察》杂志上的发现分析显示，诊断和性别对后扣带回皮质的内在功能连通性、区域同质性和几个皮质区域的体素镜像同源连通性(VMHC)有显著的主效应，主要集中在默认的网络中线。诊断性别的相互作用仅限于枕背外侧皮质，自闭症女性的VMHC减少。对于不同的前处理步骤，所有的发现都是可靠的。独立样本的可重复性因R-fMRI测量方法和效果的不同而不同，目标性别与诊断的交互作用在两个复制样本中较大的一个中复制-EU-AIMS LEAP。鉴于迄今可用的发现和复制数据集之间缺乏先验的协调，与样本有关的差异仍然存在，并可能影响到可复制性。非典型的跨半球相互作用与自闭症的神经生物学相关。它们很可能是性别依赖和性别非依赖因素的组合，在功能皮层网络中的不同影响。需要对促进可复制性的因素进行系统评估，并需要在各研究之间进行协调的大规模数据收集。
Marked sex differences in autism prevalence accentuate the need to understand the role of biological sex-related factors in autism. Efforts to unravel sex differences in the brain organization of autism have, however, been challenged by the limited availability of female data. We addressed this gap by using a large sample of males and females with autism and neurotypical (NT) control individuals (ABIDE; Autism: 362 males, 82 females; NT: 409 males, 166 females; 7–18 years). Discovery analyses examined main effects of diagnosis, sex and their interaction across five resting-state fMRI (R-fMRI) metrics (voxel-level Z > 3.1, cluster-level P < 0.01, gaussian random field corrected). Secondary analyses assessed the robustness of the results to different pre-processing approaches and their replicability in two independent samples: the EU-AIMS Longitudinal European Autism Project (LEAP) and the Gender Explorations of Neurogenetics and Development to Advance Autism Research. Discovery analyses in ABIDE revealed significant main effects of diagnosis and sex across the intrinsic functional connectivity of the posterior cingulate cortex, regional homogeneity and voxel-mirrored homotopic connectivity (VMHC) in several cortical regions, largely converging in the default network midline. Sex-by-diagnosis interactions were confined to the dorsolateral occipital cortex, with reduced VMHC in females with autism. All findings were robust to different pre-processing steps. Replicability in independent samples varied by R-fMRI measures and effects with the targeted sex-by-diagnosis interaction being replicated in the larger of the two replication samples—EU-AIMS LEAP. Given the lack of a priori harmonization among the discovery and replication datasets available to date, sample-related variation remained and may have affected replicability. Atypical cross-hemispheric interactions are neurobiologically relevant to autism. They likely result from the combination of sex-dependent and sex-independent factors with a differential effect across functional cortical networks. Systematic assessments of the factors contributing to replicability are needed and necessitate coordinated large-scale data collection across studies.
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影响因子：
11
作者：
Di Martino, A.;Yan, C-G;Li, Q.;Denio, E.;Castellanos, F. X.;Alaerts, K.;Anderson, J. S.;Assaf, M.;Bookheimer, S. Y.;Dapretto, M.;Deen, B.;Delmonte, S.;Dinstein, I.;Ertl-Wagner, B.;Fair, D. A.;Gallagher, L.;Kennedy, D. P.;Keown, C. L.;Keysers, C.;Lainhart, J. E.;Lord, C.;Luna, B.;Menon, V.;Minshew, N. J.;Monk, C. S.;Mueller, S.;Mueller, R. A.;Nebel, M. B.;Nigg, J. T.;O'Hearn, K.;Pelphrey, K. A.;Peltier, S. J.;Rudie, J. D.;Sunaert, S.;Thioux, M.;Tyszka, J. M.;Uddin, L. Q.;Verhoeven, J. S.;Wenderoth, N.;Wiggins, J. L.;Mostofsky, S. H.;Milham, M. P.
通讯作者：
Milham, M. P.
影响因子：
11.2
作者：
De Fossé, L;Hodge, SM;Harris, GJ
通讯作者：
Harris, GJ
DOI：
10.1016/j.bpsc.2020.08.008
发表时间：
2021-08-05
影响因子：
5.9
作者：
Floris, Dorothea L.;Wolfers, Thomas;Beckmann, Christian F.
通讯作者：
Beckmann, Christian F.
影响因子：
2.5
作者：
Flagg, EJ;Cardy, JEO;Roberts, TPL
通讯作者：
Roberts, TPL
探索人类大脑功能的科学
DOI：
10.1073/pnas.0911855107
发表时间：
2010-03-09
影响因子：
11.1
作者：
Biswal, Bharat B.;Mennes, Maarten;Milham, Michael P.
通讯作者：
Milham, Michael P.