Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness.
Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness.
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胃肠道病理生理学失调：肠道微生物组在海湾战争疾病中的作用
DOI：
10.1111/jcmm.17631
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发表时间：
2023-04
影响因子：
5.3
通讯作者：
中科院分区：
文献类型：
--
作者：
据报道，海湾战争疾病（GWI）在25%-35%的退伍军人从海湾战争返回。GWI的症状多种多样，包括神经和胃肠道症状以及慢性疲劳。GWI的发生与化学品暴露有关，特别是与溴化吡啶斯的明（PB）和氯菊酯的暴露有关。最近的研究发现，GWI的病理学与肠道微生物群的变化有关，即肠道生态失调。在使用动物模型的研究中，暴露于PB和氯菊酯导致肠道微生物组的变化与GWI退伍军人中发现的变化相似。使用动物模型的研究还表明，姜黄素等植物化学物质有助于减轻症状，并且从肠道细菌和肠上皮释放的细胞外囊泡（EV）可以通过细胞间通讯机制促进疾病并抑制疾病。肠上皮细胞产生EV，并且发现这些肠上皮来源的EV抑制炎性肠病的严重程度，表明在治疗中利用EV的益处。相反，来自脓毒症小鼠血浆的EV增强了体外促炎细胞因子以及体内中性粒细胞和巨噬细胞的水平，这表明EV的差异取决于它们来源的细胞类型和/或环境变化的影响。这些研究表明，靶向具有积极影响的EV可能成为治疗GWI退伍军人的新治疗策略。
Gulf War Illness (GWI) has been reported in 25%–35% of veterans returned from the Gulf war. Symptoms of GWI are varied and include both neurological and gastrointestinal symptoms as well as chronic fatigue. Development of GWI has been associated with chemical exposure particularly with exposure to pyridostigmine bromide (PB) and permethrin. Recent studies have found that the pathology of GWI is connected to changes in the gut microbiota, that is the gut dysbiosis. In studies using animal models, the exposure to PB and permethrin resulted in similar changes in the gut microbiome as these found in GW veterans with GWI. Studies using animal models have also shown that phytochemicals like curcumin are beneficial in reducing the symptoms and that the extracellular vesicles (EV) released from gut bacteria and from the intestinal epithelium can both promote diseases and suppress diseases through the intercellular communication mechanisms. The intestinal epithelium cells produce EVs and these EVs of intestinal epithelium origin are found to suppress inflammatory bowel disease severity, suggesting the benefits of utilizing EV in treatments. On the contrary, EV from the plasma of septic mice enhanced the level of proinflammatory cytokines in vitro and neutrophils and macrophages in vivo, suggesting differences in the EV depending on the types of cells they were originated and/or influences of environmental changes. These studies suggest that targeting the EV that specifically have positive influences may become a new therapeutic strategy in the treatment of veterans with GWI.
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影响因子：
12.8
作者：
Chelakkot C;Choi Y;Kim DK;Park HT;Ghim J;Kwon Y;Jeon J;Kim MS;Jee YK;Gho YS;Park HS;Kim YK;Ryu SH
通讯作者：
Ryu SH
影响因子：
5.9
作者：
Bose D;Saha P;Mondal A;Fanelli B;Seth RK;Janulewicz P;Sullivan K;Lasley S;Horner R;Colwell RR;Shetty AK;Klimas N;Chatterjee S
通讯作者：
Chatterjee S
DOI：
10.1073/pnas.0803601105
发表时间：
2008-07-01
影响因子：
11.1
作者：
Gertsch, Juerg;Leonti, Marco;Zimmer, Andreas
通讯作者：
Zimmer, Andreas
影响因子：
56.9
作者：
Gill, Steven R.;Pop, Mihai;Nelson, Karen E.
通讯作者：
Nelson, Karen E.
影响因子：
4.7
作者：
Hernandez S;Morales-Soto W;Grubišić V;Fried D;Gulbransen BD
通讯作者：
Gulbransen BD