Associations of severe adverse perinatal outcomes among continuous birth weight percentiles on different birth weight charts: a secondary analysis of a cluster randomized trial.
Associations of severe adverse perinatal outcomes among continuous birth weight percentiles on different birth weight charts: a secondary analysis of a cluster randomized trial.
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DOI：
10.1186/s12884-022-04680-5
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发表时间：
2022-04-30
影响因子：
3.1
通讯作者：
Henrichs, Jens
中科院分区：
文献类型：
--
作者：
Kamphof, Hester D.;Gordijn, Sanne J.;Ganzevoort, Wessel;Verfaille, Viki;Offerhaus, Pien M.;Franx, Arie;Pajkrt, Eva;de Jonge, Ank;Henrichs, Jens
关键词：
旨在确定两张荷兰出生体重表和一张国际出生体重表中不同出生体重百分位的新生儿发生严重不良围产期结局的风险。生长受限的新生儿在子宫内尚未达到其内在生长潜力，面临围产期发病和死亡的风险。胎儿出生后生长受限的诊断尚无明确的金标准。估计的胎儿体重和低于第 10 个百分位数的出生体重通常用作生长受限的代表。出生体重表的选择会影响出生体重被定义为异常的具体界限，从而触发临床管理。理想情况下，这种界限应该适当地区分严重不良围产期结局的低风险和高风险新生儿，从而正确地为临床管理提供信息。这是 IUGR 风险选择 (IRIS) 研究的二次分析。怀孕初期处于低风险状态并在荷兰接受初级产前护理的妇女新生儿 (n = 12 953) 被纳入其中。我们通过对出生体重百分位组进行分类并比较严重不良围产期结局的预后表现，检查了三种出生体重图表（Visser、Hoftiezer 和 INTERGROWTH）的严重不良围产期结局在出生体重百分位之间的分布。严重不良围产期结局被定义为以下一项或多项的综合结果：围产期死亡、5分钟阿普加评分 < 4、意识障碍、窒息、癫痫、辅助通气、败血症、脑膜炎、支气管肺发育不良、脑室内出血、脑室周围白质软化或坏死性小肠结肠炎。我们发现最小新生儿（< 第 3 个百分位）的严重不良围产期结局发生率最高（Visser 参考曲线为 6.2%，Hoftiezer 图表为 8.6%，INTERGROWTH 图表为 12.0%）。三个出生体重图在整个出生体重百分位数范围内的区分能力较差，曲线下面积范围为 0.57 至 0.61。各种截止值的敏感度也很低。所有三个图表在识别严重不良围产期结局的高风险方面的临床效用都很差。没有单一的界限可以清楚地区分低风险或高风险的新生儿。荷兰试用注册 NTR4367。报名日期2014年3月20日。
To identify neonatal risk for severe adverse perinatal outcomes across birth weight centiles in two Dutch and one international birth weight chart. Growth restricted newborns have not reached their intrinsic growth potential in utero and are at risk of perinatal morbidity and mortality. There is no golden standard for the confirmation of the diagnosis of fetal growth restriction after birth. Estimated fetal weight and birth weight below the 10th percentile are generally used as proxy for growth restriction. The choice of birth weight chart influences the specific cut-off by which birth weight is defined as abnormal, thereby triggering clinical management. Ideally, this cut-off should discriminate appropriately between newborns at low and at high risk of severe adverse perinatal outcomes and consequently correctly inform clinical management. This is a secondary analysis of the IUGR Risk Selection (IRIS) study. Newborns (n = 12 953) of women with a low-risk status at the start of pregnancy and that received primary antenatal care in the Netherlands were included. We examined the distribution of severe adverse perinatal outcomes across birth weight centiles for three birth weight charts (Visser, Hoftiezer and INTERGROWTH) by categorizing birth weight centile groups and comparing the prognostic performance for severe adverse perinatal outcomes. Severe adverse perinatal outcomes were defined as a composite of one or more of the following: perinatal death, Apgar score < 4 at 5 min, impaired consciousness, asphyxia, seizures, assisted ventilation, septicemia, meningitis, bronchopulmonary dysplasia, intraventricular hemorrhage, periventricular leukomalacia, or necrotizing enterocolitis. We found the highest rates of severe adverse perinatal outcomes among the smallest newborns (< 3rd percentile) (6.2% for the Visser reference curve, 8.6% for the Hoftiezer chart and 12.0% for the INTERGROWTH chart). Discriminative abilities of the three birth weight charts across the entire range of birth weight centiles were poor with areas under the curve ranging from 0.57 to 0.61. Sensitivity rates of the various cut-offs were also low. The clinical utility of all three charts in identifying high risk of severe adverse perinatal outcomes is poor. There is no single cut-off that discriminates clearly between newborns at low or high risk. Netherlands Trial Register NTR4367. Registration date March 20th, 2014.
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DOI：
10.1016/j.lanepe.2021.100167
发表时间：
2021-09
期刊：
The Lancet regional health. Europe
影响因子：
--
作者：
Hocquette A;Durox M;Wood R;Klungsøyr K;Szamotulska K;Berrut S;Rihs T;Kyprianou T;Sakkeus L;Lecomte A;Zile I;Alexander S;Klimont J;Barros H;Gatt M;Isakova J;Blondel B;Gissler M;Zeitlin J
通讯作者：
Zeitlin J
影响因子：
5.1
作者：
Beune, Irene M.;Bloomfield, Frank H.;Gordijn, Sanne J.
通讯作者：
Gordijn, Sanne J.
影响因子：
5.7
作者：
Batalle, Dafnis;Eixarch, Elisenda;Gratacos, Eduard
通讯作者：
Gratacos, Eduard
DOI：
10.1080/14767058.2016.1240161
发表时间：
2017-01-01
影响因子：
1.8
作者：
Dowdall, Danielle;Flatley, Christopher;Kumar, Sailesh
通讯作者：
Kumar, Sailesh
DOI：
10.1136/bmj.g14
发表时间：
2014-01-23
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Jaddoe VW;de Jonge LL;Hofman A;Franco OH;Steegers EA;Gaillard R
通讯作者：
Gaillard R