Advances in research based on antibody-cell conjugation.
Advances in research based on antibody-cell conjugation.
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DOI：
10.3389/fimmu.2023.1310130
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发表时间：
2023
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
抗体-细胞偶联技术是近年来医学和生物技术领域的一个新的研究方向。ACC的概念由Hsiao等提出，并发展成为一种活细胞治疗技术，指的是具有特定功能的细胞。如自然杀伤细胞（NK细胞）、细胞因子诱导的杀伤细胞（CIK细胞）等免疫细胞通过接头与单克隆抗体共同形成偶联物。ACC通过简单有效的化学偶联方法直接修饰细胞表面的特异性抗体，使细胞具有新的功能。ACC已被开发用于治疗各种疾病，包括血液系统癌症和实体瘤。本文综述了当前ACC的建设方法、面临的挑战和未来的发展方向。
Antibody-cell conjugation (ACC) technology is a new research direction in medicine and biotechnology in recent years. The concept of ACC was proposed by Hsiao et al. and developed into a viable cell therapy technology, which refers to the cells with specific functions. Such as natural killer cells (NK cells), cytokine induced killer cells (CIK) and other immune cells and monoclonal antibodies through the linker together formed conjugate. ACC directly modifies specific antibodies on the cell surface through a simple and effective chemical coupling method to enable cells to have new functions. ACC has been developed for the treatment of various diseases, including cancers of the blood system and solid tumors. This paper reviews the current ACC construction methods, challenges and future development directions.
酪氨酸酶介导的纳米型细胞结合物的合成。
影响因子：
18.2
作者：
Maza, Johnathan C.;Garcia-Almedina, Derek M.;Boike, Lydia E.;Hamlish, Noah X.;Nomura, Daniel K.;Francis, Matthew B.
通讯作者：
Francis, Matthew B.
影响因子：
16.6
作者：
Zheng, Tianqing;Jiang, Hao;Gros, Marilyn;del Amo, David Soriano;Sundaram, Subha;Lauvau, Gregoire;Marlow, Florence;Liu, Yi;Stanley, Pamela;Wu, Peng
通讯作者：
Wu, Peng