Unconventional animal models for traumatic brain injury and chronic traumatic encephalopathy.
Unconventional animal models for traumatic brain injury and chronic traumatic encephalopathy.
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DOI：
10.1002/jnr.24920
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发表时间：
2021-10
影响因子：
4.2
通讯作者：
Hof PR
中科院分区：
文献类型：
--
作者：
Ackermans NL;Varghese M;Wicinski B;Torres J;De Gasperi R;Pryor D;Elder GA;Gama Sosa MA;Reidenberg JS;Williams TM;Hof PR
创伤性脑损伤（TBI）是全世界死亡的主要原因之一。这是一种复杂的损伤，会影响细胞生理学、导致神经元细胞死亡并影响大脑中的分子通路。这反过来会导致感觉、运动和行为的改变，从而深刻影响生活质量。重复性轻度 TBI 可发展为慢性创伤性脑病 (CTE)，这是一种与严重行为改变相关的神经退行性疾病。虽然目前的 TBI 和 CTE 动物模型（例如啮齿动物）可用于探索受影响的途径，但其中的临床发现很少转化为临床应用，可能是因为模型动物和人类之间存在许多形态功能差异。因此，用替代动物模型来补充这些研究非常重要，这些动物模型可以更好地复制人类 TBI 的个性。对具有自然进化的大脑保护功能的动物（如大角羊、啄木鸟和鲸鱼）进行的比较研究可能为人类提供预防性应用。深入研究这些非传统动物有三个好处。首先，增加对经常被研究的物种的了解；其次，在极端动物模型的基础上改进常见动物模型；最后，挖掘生物学灵感的来源，进行人类的比较研究和转化应用。
Traumatic brain injury (TBI) is one of the main causes of death worldwide. It is a complex injury that influences cellular physiology, causes neuronal cell death, and affects molecular pathways in the brain. This in turn can result in sensory, motor, and behavioral alterations that deeply impact the quality of life. Repetitive mild TBI can progress into chronic traumatic encephalopathy (CTE), a neurodegenerative condition linked to severe behavioral changes. While current animal models of TBI and CTE such as rodents, are useful to explore affected pathways, clinical findings therein have rarely translated into clinical applications, possibly because of the many morphofunctional differences between the model animals and humans. It is therefore important to complement these studies with alternative animal models that may better replicate the individuality of human TBI. Comparative studies in animals with naturally evolved brain protection such as bighorn sheep, woodpeckers, and whales, may provide preventive applications in humans. The advantages of an in‐depth study of these unconventional animals are threefold. First, to increase knowledge of the often‐understudied species in question; second, to improve common animal models based on the study of their extreme counterparts; and finally, to tap into a source of biological inspiration for comparative studies and translational applications in humans.
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影响因子：
4.1
作者：
CAREY, ME;SARNA, GS;HAPPEL, LT
通讯作者：
HAPPEL, LT
影响因子：
16.6
作者：
Arneson D;Zhang G;Ying Z;Zhuang Y;Byun HR;Ahn IS;Gomez-Pinilla F;Yang X
通讯作者：
Yang X
影响因子：
81.5
作者：
Blennow, Kaj;Brody, David L.;Zetterberg, Henrik
通讯作者：
Zetterberg, Henrik
DOI：
10.1016/0020-1383(82)90057-2
发表时间：
1982-01-01
影响因子：
2.5
作者：
ALLEN, IV;SCOTT, R;TANNER, JA
通讯作者：
TANNER, JA
影响因子：
1.4
作者：
BAKER, CS;HERMAN, LM
通讯作者：
HERMAN, LM