Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis
Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis
复制标题
口服葡萄糖胺、甲基磺酰甲烷及其组合治疗骨关节炎的随机、双盲、平行、安慰剂对照研究
作者：
P. Usha;M. Naidu
摘要目的：氨基葡萄糖是一种有效的软骨保护剂，属于骨关节炎的慢作用药物。甲基磺酰甲烷（MSM）是二甲基亚砜（DSMO）的异氧化形式，是一种有效的天然镇痛和抗炎剂。本研究的目的是比较口服氨基葡萄糖（Glu）、甲基磺酰甲烷（MSM）、其组合和安慰剂治疗膝关节骨关节炎的有效性和安全性。
患者和设计：共有118名患有轻度至中度骨关节炎的男女患者被纳入研究，并随机接受Glu 500 mg、MSM 500 mg、Glu和MSM或安慰剂胶囊，每日三次，持续12周。在治疗后0周（给药前）、2周、4周、8周和12周评价患者的疗效和安全性。研究的疗效参数为疼痛指数、肿胀指数、视觉模拟评分疼痛强度、15 m步行时间、Lequesne指数和急救药物消耗量。
结果：与安慰剂相比，Glu、MSM及其组合显著改善骨关节炎的体征和症状。平均（± SD）疼痛指数从基线时的1.74 ± 0.47降低至第12周时的0.65 ± 0.71，具有统计学显著性（p < 0.001）。MSM使平均疼痛指数从1.53 ± 0.51显著降低至0.74 ± 0.65，并且联合治疗导致平均疼痛指数更显著降低（1.7 ± 0.47至0.36 ± 0.33; p < 0.001）。12周后，Glu和MSM组的平均肿胀指数显著降低，而联合治疗组的肿胀指数降低幅度更大（1.43 ± 0.63至0.14 ± 0.35; p < 0.05）。该组合产生了Lequesne指数的统计学显著下降。所有治疗均耐受良好。
结论：Glu、MSM及其联合应用对骨关节炎有镇痛抗炎作用。联合治疗在减轻疼痛和肿胀以及改善关节功能方面比单独药物表现出更好的疗效。所有治疗均耐受良好。镇痛和抗炎活性的发作被发现是更快的组合比与Glu。可以得出结论，MSM与Glu的组合在骨关节炎患者中提供了更好和更快的改善。
AbstractObjective: Glucosamine, classified as a slow-acting drug in osteoarthritis (SADOA), is an efficacious chondroprotective agent. Methylsulfonylmethane (MSM), the isoxidised form of dimethyl-sulfoxide (DSMO), is an effective natural analgesic and anti-inflammatory agent. The aim of this study was to compare the efficacy and safety of oral glucosamine (Glu), methylsulfonylmethane (MSM), their combination and placebo in osteoarthritis of the knee.
Patients and design: A total of 118 patients of either sex with mild to moderate osteoarthritis were included in the study and randomised to receive either Glu 500mg, MSM 500mg, Glu and MSM or placebo capsules three times daily for 12 weeks. Patients were evaluated at 0 (before drug administration), 2, 4, 8 and 12 weeks post-treatment for efficacy and safety. The efficacy parameters studied were the pain index, the swelling index, visual analogue scale pain intensity, 15m walking time, the Lequesne index, and consumption of rescue medicine.
Results: Glu, MSM and their combination significantly improved signs and symptoms of osteoarthritis compared with placebo. There was a statistically significant decrease in mean (± SD) pain index from 1.74 ± 0.47 at baseline to 0.65 ± 0.71 at week 12 with Glu (p < 0.001). MSM significantly decreased the mean pain index from 1.53 ± 0.51 to 0.74 ± 0.65, and combination treatment resulted in a more significant decrease in the mean pain index (1.7 ± 0.47 to 0.36 ± 0.33; p < 0.001). After 12 weeks, the mean swelling index significantly decreased with Glu and MSM, while the decrease in swelling index with combination therapy was greater (1.43 ± 0.63 to 0.14 ± 0.35; p < 0.05) after 12 weeks. The combination produced a statistically significant decrease in the Lequesne index. All treatments were well tolerated.
Conclusion: Glu, MSM and their combination produced an analgesic and anti-inflammatory effect in osteoarthritis. Combination therapy showed better efficacy in reducing pain and swelling and in improving the functional ability of joints than the individual agents. All the treatments were well tolerated. The onset of analgesic and anti-inflammatory activity was found to be more rapid with the combination than with Glu. It can be concluded that the combination of MSM with Glu provides better and more rapid improvement in patients with osteoarthritis.
甲氯芬那酸钠一水合物抑制趋化因子诱导的人多形核白细胞功能。
影响因子：
--
作者：
Perez,HD;Elfman,F;Marder,S
通讯作者：
Marder,S