Metabolism of fructose to oxalate and glycolate.
Metabolism of fructose to oxalate and glycolate.
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DOI：
10.1055/s-0030-1265145
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Holmes RP
中科院分区：
文献类型：
--
作者：
Knight J;Assimos DG;Easter L;Holmes RP
最近，果糖的消费引起了人们的极大关注，因为它与肥胖和随后的慢性疾病的发展有关。最近有报道称，果糖摄入量增加会增加形成肾结石的风险。据推测，果糖消费可能会增加尿草酸盐，草酸钙肾结石疾病的危险因素。然而，在研究果糖代谢和草酸合成之间关系的人体研究中，得到了相互矛盾的结果。为了测试果糖摄入量是否会影响尿排泄，从而影响肾结石风险，健康受试者食用控制果糖、草酸盐、钙和其他营养素含量的饮食。受试者以随机顺序食用含有4%、13%和21%卡路里的果糖的饮食。未观察到草酸、钙和尿酸排泄的变化。在体外培养的肝细胞与13 C-标记的糖孵育的调查表明，既不是果糖也不是葡萄糖转化为草酸这些细胞。果糖代谢占培养基中检测到的乙醇酸盐的12.4 ± 1.6%，葡萄糖代谢占6.4 ± 0.9%。我们的研究结果表明，与果糖摄入相关的结石风险机制可能存在于影响尿液中主要结石风险参数的因素之外。
Much attention has been recently directed at fructose consumption because of its association with obesity and subsequent development of chronic diseases. It was recently reported that an increased fructose intake increases the risk of forming kidney stones. It was postulated that fructose consumption may increase urinary oxalate, a risk factor for calcium oxalate kidney stone disease. However, conflicting results have been obtained in human studies examining the relationship between fructose metabolism and oxalate synthesis. To test whether fructose intake influences urinary excretions impacting kidney stone risk, healthy subjects consumed diets controlled in their contents of fructose, oxalate, calcium, and other nutrients. Subjects consumed diets containing 4, 13, and 21% of calories as fructose in a randomized order. No changes in the excretions of oxalate, calcium, and uric acid were observed. In vitro investigations with cultured liver cells incubated with 13C-labeled sugars indicated that neither fructose nor glucose was converted to oxalate by these cells. Fructose metabolism accounted for 12.4 ± 1.6% of the glycolate detected in the culture medium and glucose 6.4 ± 0.9%. Our results suggest that mechanisms for stone risk associated with fructose intake may lie in factors other than those affecting the major stone risk parameters in urine.
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影响因子：
19.6
作者：
Sakhaee, Khashayar
通讯作者：
Sakhaee, Khashayar
影响因子：
19.6
作者：
Taylor, E. N.;Curhan, G. C.
通讯作者：
Curhan, G. C.
影响因子：
4.1
作者：
Chang, SH;Garcia, J;Agarwal, A
通讯作者：
Agarwal, A
影响因子：
5.5
作者：
Baker, PRS;Cramer, SD;Holmes, RP
通讯作者：
Holmes, RP
DOI：
10.1038/icb.1980.10
发表时间：
1980-01-01
期刊：
AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE
影响因子：
--
作者：
ROFE, AM;JAMES, HM;CONYERS, RAJ
通讯作者：
CONYERS, RAJ