Surface Chemistry Study of the Interactions of Sesame Oil with Meibomian Films.
Surface Chemistry Study of the Interactions of Sesame Oil with Meibomian Films.
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DOI：
10.3390/molecules27020464
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发表时间：
2022-01-11
期刊：
影响因子：
--
通讯作者：
Georgiev GA
中科院分区：
文献类型：
--
作者：
Eftimov P;Yokoi N;Georgiev GA
一种可能的治疗眉板腺疾病(MGD)的方法是用富含非极性脂(NPL)的植物油补充眉板腺分泌物(MGS)。芝麻油(SO)在单不饱和脂肪(油酸，占总量的40%)和多不饱和脂肪(亚油酸，占总量的42%)中的含量大致相当，由于其抗炎和抗氧化作用，已显示出多种健康益处。因此，表层SO和MGS之间的相互作用值得进一步研究。因此，控制MGS/SO摩尔比(0%、10%、30%、50%和100%SO)在磷酸盐缓冲盐水(pH 7.4)亚相上在朗缪尔槽的空气/水表面形成伪二元膜。表面压力(π)-面积(A)等温线和布鲁斯特角显微镜观察表明，SO与MG聚集在一起，并补充了眉毛层的NPL层，这是不理想的相互作用。用Kohlrausch-Williams-Watts方程对薄膜的应力松弛过程进行了分析，结果表明，适量的MgS与过量的脂质一起加入改变了薄膜的膨胀弹性，表现为β指数的增大。因此，SO具有高氧化稳定性和丰富的长多不饱和酰基链的独特组合，可能是对MGS层的有益补充。
A possible approach for the treatment of meibomian gland disease (MGD) can be the supplementation of meibomian gland secretion (MGS) with nonpolar lipids (NPL) rich plant oils. Sesame oil (SO), approximately equal in monounsaturated fat (oleic acid, 40% of total) and polyunsaturated fat (linoleic acid, 42% of total), has shown multiple health benefits due to its anti-inflammatory and antioxidant effects. Thus, the interactions between SO and MGS in surface layers deserve further study. Therefore, pseudobinary films were formed with controlled MGS/SO molar ratios (0%, 10%, 30%, 50%, and 100% SO) at the air/water surface of the Langmuir trough over phosphate buffered saline (pH 7.4) subphase. Surface pressure (π)-area (A) isotherms and Brewster angle microscopy observations showed nonideal interactions where SO aggregates with MGS and complements the NPL stratum of the meibomian layers. The analysis of stress relaxation transients with Kohlrausch–Williams–Watts equation revealed that the supplementation of fixed amount of MGS with excess lipids via SO altered the dilatational elasticity of the films as reflected by the increase of the exponent β. Thus, SO with its unique combination of high oxidative stability and abundance of long polyunsaturated acyl chains might be a useful supplement to MGS layers.
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影响因子：
3.5
作者：
Avramov, I
通讯作者：
Avramov, I
影响因子：
3.4
作者：
Ewurum A;Ankem A;Georgiev G;Borchman D
通讯作者：
Borchman D
DOI：
10.1136/bjo.2008.156828
发表时间：
2009-11
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
Mochizuki H;Yamada M;Hatou S;Tsubota K
通讯作者：
Tsubota K
影响因子：
3.4
作者：
BURSH, T;LARSSON, K;LUNDQUIS.M
通讯作者：
LUNDQUIS.M
影响因子：
4.4
作者：
Butovich, Igor A.;Arciniega, Juan C.;Wojtowicz, Jadwiga C.
通讯作者：
Wojtowicz, Jadwiga C.