New Latency Reversing Agents for HIV-1 Cure: Insights from Nonhuman Primate Models.
New Latency Reversing Agents for HIV-1 Cure: Insights from Nonhuman Primate Models.
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DOI：
10.3390/v13081560
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发表时间：
2021-08-06
期刊：
影响因子：
--
通讯作者：
Mavigner M
中科院分区：
文献类型：
--
作者：
Bricker KM;Chahroudi A;Mavigner M
抗逆转录病毒疗法（ART）控制人类免疫缺陷病毒1（HIV-1）的复制，防止疾病进展，但不能根除HIV-1。潜伏感染细胞库的持续存在是治愈的主要障碍。“休克和杀死”是一种有前途的策略，涉及潜伏逆转剂（LRA）以从潜伏感染的细胞中重新激活HIV-1，从而使感染的细胞暴露于免疫系统或清除剂的杀死。在这里，我们回顾了通过非人灵长类动物（NHP）模型的“休克和杀死”策略的进展，强调最近发现的潜伏期逆转剂和方法，如模拟的第二线粒体激活剂半胱天冬酶（SMACm），实验CD 8 + T细胞耗竭，免疫检查点阻断（ICI），和Toll样受体（TLR）激动剂。我们还讨论了NHP模型用于HIV治愈研究的优点和局限性，以及开发用于评估NHP中LRA体内治疗疗效的方法。
Antiretroviral therapy (ART) controls human immunodeficiency virus 1 (HIV-1) replication and prevents disease progression but does not eradicate HIV-1. The persistence of a reservoir of latently infected cells represents the main barrier to a cure. “Shock and kill” is a promising strategy involving latency reversing agents (LRAs) to reactivate HIV-1 from latently infected cells, thus exposing the infected cells to killing by the immune system or clearance agents. Here, we review advances to the “shock and kill” strategy made through the nonhuman primate (NHP) model, highlighting recently identified latency reversing agents and approaches such as mimetics of the second mitochondrial activator of caspase (SMACm), experimental CD8+ T cell depletion, immune checkpoint blockade (ICI), and toll-like receptor (TLR) agonists. We also discuss the advantages and limits of the NHP model for HIV cure research and methods developed to evaluate the efficacy of in vivo treatment with LRAs in NHPs.
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影响因子：
64.8
作者：
Borducchi, Erica N.;Cabral, Crystal;Stephenson, Kathryn E.;Liu, Jinyan;Abbink, Peter;Ng'ang'a, David;Nkolola, Joseph P.;Brinkman, Amanda L.;Peter, Lauren;Lee, Benjamin C.;Jimenez, Jessica;Jetton, David;Mondesir, Jade;Mojta, Shanell;Chandrashekar, Abishek;Molloy, Katherine;Alter, Galit;Gerold, Jeffrey M.;Hill, Alison L.;Lewis, Mark G.;Pau, Maria G.;Schuitemaker, Hanneke;Hesselgesser, Joseph;Geleziunas, Romas;Kim, Jerome H.;Robb, Merlin L.;Michael, Nelson L.;Barouch, Dan H.
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DOI：
10.1073/pnas.95.15.8869
发表时间：
1998-07-21
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
3.8
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