Multi-channel near-infrared spectroscopy reveals reduced prefrontal activation in schizophrenia patients during performance of the kana Stroop task.
Multi-channel near-infrared spectroscopy reveals reduced prefrontal activation in schizophrenia patients during performance of the kana Stroop task.
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多通道近红外光谱显示精神分裂症患者在执行假名斯特鲁普任务期间前额叶激活减少。
DOI：
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发表时间：
2012
影响因子：
0.7
通讯作者：
T. Ohmori
中科院分区：
文献类型：
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作者：
Kyoko Taniguchi;Satsuki Sumitani;Y. Watanabe;Mai Akiyama;T. Ohmori
本研究的目的是通过近红外光谱(NIRS)测量氧合血红蛋白(OxHb)浓度的变化来观察精神分裂症患者在两种日语Stroop任务(假名和汉字)执行过程中额叶的活动。14名精神分裂症患者和14名年龄和性别匹配的健康对照组在同意后参与了这项研究。在Stroop任务执行过程中，用近红外光谱测量氧合Hb浓度的相对变化。在假名和汉字版本中，都观察到了显著的Stroop效应，以正确回答的数量来衡量。对NIRS数据的分析表明，与健康对照组相比，精神分裂症患者在执行Kana Stroop任务时，前额皮质的激活减少，而精神分裂症患者和健康对照组在执行Kanji Stroop任务时，前额皮质都缺乏活动。本研究的结果表明，假名Stroop任务引起的Stroop效应可能比Kanji Stroop任务更大，精神分裂症患者表现出与执行Kana Stroop任务所需的抑制有关的前额叶血管反应性降低。
The purpose of the present study was to investigate the activity of frontal lobe of patients with schizophrenia during performance of two Japanese versions of the Stroop task (kana and kanji) by measuring changes in the concentration of oxygenated hemoglobin (oxyHb) with near-infrared spectroscopy (NIRS). Fourteen schizophrenia patients and 14 age- and gender-matched healthy control subjects participated in the study after giving consent. The relative changes of concentrations of oxyHb were measured by NIRS during performance of the Stroop task. Significant Stroop effects, as measured by the number of correct responses, were observed with both the kana and the kanji versions. Analysis of NIRS data revealed that the schizophrenia patients showed reduced activation in the prefrontal cortex compared to healthy controls during performance of the kana Stroop task, and that both schizophrenia patients and healthy controls showed lack of activity in the prefrontal cortex during performance of the kanji Stroop task. The results of the present study suggest the possibility that the kana Stroop task cause a greater Stroop effect than the kanji Stroop task, and schizophrenia patients show decreased prefrontal vascular reactivity associated with the inhibition required during the performance of the kana Stroop task.
影响因子：
17.7
作者：
Kerns, JG;Cohen, JD;Carter, CS
通讯作者：
Carter, CS