Is shock a key element in the pathology of sudden infant death syndrome (SIDS)?
Is shock a key element in the pathology of sudden infant death syndrome (SIDS)?
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DOI：
10.1177/1099800408324854
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发表时间：
2009-10
影响因子：
2.5
通讯作者：
Lorimer M
中科院分区：
文献类型：
--
作者：
Blood-Siegfried J;Bowers MT;Lorimer M
在发达国家，婴儿猝死综合症（SIDS）是1个月至1岁婴儿死亡的最常见原因。小岛屿发展中国家的病因可能是多因素的，目前的模式往往描述三个重叠的风险因素。这些因素是一个关键的发展时期，一个脆弱的婴儿和一个或多个外源性压力。在“三重风险模型”中，SIDS婴儿被描述为在自主控制发展的关键时期期间在中枢神经系统中具有心肺控制的潜在脆弱性。这种脆弱性可能会影响对外源性压力的反应，包括俯卧位，缺氧和二氧化碳增加。在“常见细菌假说”和“致命三角”中，重点是压力源。常见的呼吸道感染的组合可导致婴儿在发育脆弱时期的SIDS。这一理论还包括三个因素的脆弱性：遗传素质，脆弱的发展年龄和感染压力。在“致命三角”理论中，感染、炎症和遗传都在引发SIDS死亡方面发挥作用。从我们在动物模型中的工作中，我们发现在发育的关键时期，大鼠幼崽死于感染性损伤的组合。这是加剧了围产期尼古丁暴露，条件表明，改变暴露后代的自主反应。我们认为休克和心血管衰竭是联系这些理论的关键因素。
In developed countries Sudden Infant Death Syndrome (SIDS) is the most common cause of death for infants between the age of 1 month and 1 year. The etiology of SIDS is likely to be multifactorial, and current paradigms often describe three overlapping elements of risk. Those elements are a critical developmental period, a vulnerable infant and one or more exogenous stressors. In the “Triple-risk Model”, SIDS infants are described as having an underlying vulnerability in cardio-respiratory control in the central nervous system during a critical period when autonomic control is developing. This vulnerability might affect the response to exogenous stressors, including prone sleep position, hypoxia and increased carbon dioxide. In the “Common Bacterial Hypothesis” and “Fatal Triangle”, the focus is on the stressors. A combination of common respiratory infections can cause SIDS in an infant during a developmentally vulnerable period. This theory also includes three factors of vulnerability: a genetic predisposition, vulnerable developmental age and infectious stressors. In the “Fatal Triangle” theory, infection, inflammation and genetics each play a role in triggering a SIDS fatality. From our work in an animal model we have found that rat pups die from a combination of infectious insults, during a critical time of development. This is exacerbated by perinatal nicotine exposure, a condition shown to alter the autonomic response in exposed offspring. We are proposing that shock and cardiovascular collapse is a key element that links these theories.
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影响因子：
5.6
作者：
KAHN, A;GROSWASSER, J;WAYENBERG, JL
通讯作者：
WAYENBERG, JL
影响因子：
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作者：
Gordon, AE;MacKenzie, DAC;Blackwell, CC
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DOI：
10.1016/s0034-5687(99)00107-3
发表时间：
2000-02-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
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作者：
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通讯作者：
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影响因子：
3.6
作者：
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通讯作者：
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DOI：
10.1093/jnen/60.3.228
发表时间：
2001-03-01
影响因子：
3.2
作者：
Kinney, HC;Filiano, JJ;White, WF
通讯作者：
White, WF