Genome-wide association study identifies common variants associated with circulating vitamin E levels.
Genome-wide association study identifies common variants associated with circulating vitamin E levels.
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DOI：
10.1093/hmg/ddr296
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发表时间：
2011-10-01
影响因子：
3.5
通讯作者：
Albanes D
中科院分区：
文献类型：
--
作者：
Major JM;Yu K;Wheeler W;Zhang H;Cornelis MC;Wright ME;Yeager M;Snyder K;Weinstein SJ;Mondul A;Eliassen H;Purdue M;Hazra A;McCarty CA;Hendrickson S;Virtamo J;Hunter D;Chanock S;Kraft P;Albanes D
在两个欧洲血统的成年人群中，我们观察到了三个与α-生育酚水平相关的基因座，两个新的单核苷酸多态(SNPs)，即19位点上的rs2108622(P=1.7x10−8)和12q24.31上的rs11057830(P=2.0×10−8)，并证实了先前报道的11q23.3上的rs964184位点(P=2.7×10−10)。据报道，这三个SNPs与脂质代谢和/或调节有关。我们在两个独立样本的联合Meta分析中重复了这些发现，P=7.8x10−12(位于BUD13、ZNF259和APOA1/C3/A4/A5附近的11q23.3上的rs964184)、P=1.4×10−10(位于19-p13.11的rs2108622)和P=8.2×10−9(位于12q24.31靠近SCARB1的rs11057830)。加在一起，这些SNP可以解释对数α-生育酚水平1.7%的残差。在两个男性GWA群中的一个(n=992)中，没有SNPs与γ-生育酚浓度显著相关，在纳入了71个独立SNPs的复制样本数据后，P<；1×10−4被确定。
In genome-wide association studies (GWAS) of common genetic variants associated with circulating alpha- and gamma-tocopherol concentrations in two adult cohorts comprising 5006 men of European descent, we observed three loci associated with alpha-tocopherol levels, two novel single-nucleotide polymorphisms (SNPs), rs2108622 on 19pter-p13.11 (P= 1.7 × 10−8) and rs11057830 on 12q24.31 (P= 2.0 × 10−8) and confirmed a previously reported locus marked by rs964184 on 11q23.3 (P= 2.7 × 10−10). The three SNPs have been reported to be associated with lipid metabolism and/or regulation. We replicated these findings in a combined meta-analysis with two independent samples, P= 7.8 × 10−12 (rs964184 on 11q23.3 near BUD13, ZNF259 and APOA1/C3/A4/A5), P= 1.4 × 10−10 (rs2108622 on 19pter-p13.11 near CYP4F2) and P= 8.2 × 10−9 (rs11057830 on 12q24.31 near SCARB1). Combined, these SNPs explain 1.7% of the residual variance in log alpha-tocopherol levels. In one of the two male GWAS cohorts (n= 992), no SNPs were significantly associated with gamma-tocopherol concentrations after including data from the replication sample for 71 independent SNPs with P< 1 × 10−4 identified.
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影响因子：
3.5
作者：
Ahn J;Yu K;Stolzenberg-Solomon R;Simon KC;McCullough ML;Gallicchio L;Jacobs EJ;Ascherio A;Helzlsouer K;Jacobs KB;Li Q;Weinstein SJ;Purdue M;Virtamo J;Horst R;Wheeler W;Chanock S;Hunter DJ;Hayes RB;Kraft P;Albanes D
通讯作者：
Albanes D
与人类血液低密度脂蛋白胆固醇、高密度脂蛋白胆固醇或甘油三酯相关的六个新位点。
影响因子：
30.8
作者：
Kathiresan, Sekar;Melander, Olle;Guiducci, Candace;Surti, Aarti;Burtt, Noel P.;Rieder, Mark J.;Cooper, Gregory M.;Roos, Charlotta;Voight, Benjamin F.;Havulinna, Aki S.;Wahlstrand, Bjorn;Hedner, Thomas;Corella, Dolores;Tai, E. Shyong;Ordovas, Jose M.;Berglund, Goran;Vartiainen, Erkki;Jousilahti, Pekka;Hedblad, Bo;Taskinen, Marja-Riitta;Newton-Cheh, Christopher;Salomaa, Veikko;Peltonen, Leena;Groop, Leif;Altshuler, David M.;Orho-Melander, Marju
通讯作者：
Orho-Melander, Marju
DOI：
10.1016/j.mrfmmm.2005.06.013
发表时间：
2005-12-30
影响因子：
2.3
作者：
Hayes, RB;Sigurdson, A;Berg, CD
通讯作者：
Berg, CD
影响因子：
30.8
作者：
Kathiresan S;Willer CJ;Peloso GM;Demissie S;Musunuru K;Schadt EE;Kaplan L;Bennett D;Li Y;Tanaka T;Voight BF;Bonnycastle LL;Jackson AU;Crawford G;Surti A;Guiducci C;Burtt NP;Parish S;Clarke R;Zelenika D;Kubalanza KA;Morken MA;Scott LJ;Stringham HM;Galan P;Swift AJ;Kuusisto J;Bergman RN;Sundvall J;Laakso M;Ferrucci L;Scheet P;Sanna S;Uda M;Yang Q;Lunetta KL;Dupuis J;de Bakker PI;O'Donnell CJ;Chambers JC;Kooner JS;Hercberg S;Meneton P;Lakatta EG;Scuteri A;Schlessinger D;Tuomilehto J;Collins FS;Groop L;Altshuler D;Collins R;Lathrop GM;Melander O;Salomaa V;Peltonen L;Orho-Melander M;Ordovas JM;Boehnke M;Abecasis GR;Mohlke KL;Cupples LA
通讯作者：
Cupples LA
影响因子：
1.9
作者：
Marchioli, R;Schweiger, C;Valagussa, F
通讯作者：
Valagussa, F