Osteoblast role in the pathogenesis of rheumatoid arthritis.
Osteoblast role in the pathogenesis of rheumatoid arthritis.
复制标题
成骨细胞在类风湿关节炎发病机制中的作用。
DOI：
10.1007/s11033-021-06288-y
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发表时间：
2021-03
影响因子：
2.8
通讯作者：
Cantatore FP
中科院分区：
文献类型：
--
作者：
Berardi S;Corrado A;Maruotti N;Cici D;Cantatore FP
在类风湿性关节炎、脊柱性关节炎、骨关节炎、骨质疏松症等几种风湿性疾病的发病机制中，成骨细胞的生长、分化和活性的改变起着重要作用。尤其在类风湿关节炎中，骨平衡受到干扰：在类风湿关节炎病程中，除了刺激破骨细胞执行的病理性骨吸收过程外，促炎细胞因子(如肿瘤坏死因子-α、白介素1)也能抑制成骨细胞的分化和功能，导致净骨丢失。类风湿性关节炎的小鼠模型表明，炎症的完全消退(最大限度地减少促炎因子的表达)对于骨愈合至关重要，这是通过成骨细胞的活动实现的。事实上，这些患者中涉及成骨细胞功能的因子和系统的异常活动已经被描述过。更好地了解成骨细胞失调的致病机制有助于解释类风湿性关节炎中发现的全身性和局灶性关节骨丢失。然而，这些方面并没有在研究中得到频繁和直接的评估。这篇综述文章重点分析了成骨细胞失调在类风湿关节炎中的作用：更好地了解这些机制有助于实现新的治疗策略。
In the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritis, osteoarthritis, osteoporosis, alterations in osteoblast growth, differentiation and activity play a role. In particular, in rheumatoid arthritis bone homeostasis is perturbed: in addition to stimulating the pathologic bone resorption process performed by osteoclasts in course of rheumatoid arthritis, proinflammatory cytokines (such as Tumor Necrosis factor-α, Interleukin-1) can also inhibit osteoblast differentiation and function, resulting in net bone loss. Mouse models of rheumatoid arthritis showed that complete resolution of inflammation (with maximal reduction in the expression of pro-inflammatory factors) is crucial for bone healing, performed by osteoblasts activity. In fact, abnormal activity of factors and systems involved in osteoblast function in these patients has been described. A better understanding of the pathogenic mechanisms involved in osteoblast dysregulation could contribute to explain the generalized and focal articular bone loss found in rheumatoid arthritis. Nevertheless, these aspects have not been frequently and directly evaluated in studies. This review article is focused on analysis of the current knowledge about the role of osteoblast dysregulation occurring in rheumatoid arthritis: a better knowledge of these mechanisms could contribute to the realization of new therapeutic strategies.
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