Psoriasis genetics: breaking the barrier.
Psoriasis genetics: breaking the barrier.
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DOI：
10.1016/j.tig.2010.06.006
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发表时间：
2010-09
影响因子：
11.4
通讯作者：
Bowcock, Anne M.
中科院分区：
文献类型：
--
作者：
Roberson, Elisha D. O.;Bowcock, Anne M.
Psoriasis is a common incurable inflammatory skin disease affecting 2–3% of the European population. Psoriatic skin contains large numbers of immune cells which produce many cytokines, chemokines and inflammatory molecules. The epidermis divides much faster than normal and has a defective outer layer or barrier which under normal circumstances protects from infection and dehydration. Psoriatic skin is characterized by a distinct set of inflammation and epidermal proliferation and differentiation markers, and it has not been clear if the genetic basis of psoriasis is due to defects of the immune system or the skin. One genetic determinant lies within the major histocompatibility complex class 1 region. Genome-wide association studies have revealed genetic susceptibility factors that play a role in the formation of immune cells found in psoriasis lesions. Others affect epidermal proliferation and the formation of the skin’s barrier. Hence, genetic components of both the immune system and the epidermis predispose to disease.
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