Membrane proteins by accident or design.
Membrane proteins by accident or design.
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膜蛋白是偶然或设计的。
DOI：
10.1016/j.cbpa.2013.10.005
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发表时间：
2013
影响因子：
7.8
通讯作者：
Simms J
中科院分区：
文献类型：
--
作者：
Simms J
提高评分功能的准确性突出了计算方法作为膜蛋白设计的辅助。尽管缺乏结构信息，膜蛋白设计在预测将执行特定功能的序列方面正变得越来越成功。膜蛋白设计将有助于理解天然膜蛋白如何折叠。蛋白质设计是创造具有所需特性的定制蛋白质以及研究序列，结构和功能关系的宝贵工具。膜蛋白设计是一个新兴的领域，由于缺乏高分辨率的结构信息而受到阻碍。尽管有这些缺点，计算方法为绘制这些疏水蛋白的蓝图提供了一条途径。结构评分和采样方法的进步使得从初级氨基酸序列中更准确地预测折叠结构成为可能。本文综述了一些新颖的研究，重点是用于成功设计膜蛋白的方法和信息。
HighlightsIncreased scoring function accuracy highlights computational methods as an aid to membrane protein design.Membrane protein design, despite a lack of structural information, is becoming increasingly successful in predicting sequences that will perform specific functions.Membrane protein design will subsequently contribute the understanding on how native membrane proteins fold.Protein design is a valuable tool to create bespoke proteins with desired properties as well as for investigating sequence, structure and function relationships. Membrane protein design is a burgeoning field that is hampered by the lack of high-resolution structural information. In spite of these shortcomings, computational methods have offered a route towards blueprints for these hydrophobic proteins. Advances in structural scoring and sampling methods are enabling more accurate predictions of a folded structure from the primary amino acid sequence. This review highlights a number of novel studies focusing on the methods and information used to successfully design membrane proteins.
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