Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings.
Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings.
复制标题
DOI：
10.1016/j.ijheh.2008.09.004
复制
发表时间：
2009-07
影响因子：
6
通讯作者：
Fu, Hua
中科院分区：
文献类型：
--
作者：
Ye, Xibiao;Qian, Haojun;Xu, Peicheng;Zhu, Lin;Longnecker, Matthew P.;Fu, Hua
美国食品和药物管理局 (FDA) 的一个科学审查小组最近发现，需要更多关于易感人群接触牙科汞合金汞的健康风险的数据。我们评估了低水平汞暴露对儿童肾功能以及神经行为和神经心理学表现的影响。牙医对上海徐汇区5所学校403名7-11岁儿童的牙科病史进行了检查。其中，招募了 198 名已确认汞合金填充物的患者（暴露组）。参考儿童（N=205）是那些从未接受过牙科汞合金治疗的儿童。 2004 年 5 月，每个孩子提供了一份尿液样本，用于测量总汞、n-乙酰基-β-D-氨基葡萄糖苷酶活性、微量白蛋白和肌酐 (Cr)。进行了儿童行为检查表、艾森克人格问卷和智力筛查测试。对于有汞合金填充物的儿童，几何平均尿汞浓度为 1.6 μg/g Cr，而对于没有汞合金填充物的儿童，几何平均尿汞浓度为 1.4 μg/g Cr。在肾功能生物标志物、神经行为、神经心理学或智力测试方面，有和没有充填的儿童之间没有发现差异。尽管汞合金填充儿童的尿汞浓度略有升高，但我们没有发现对评估结果产生不利影响的证据。这些结果与发达国家最近的试验结果一致。
A scientific review panel for the U.S. Food and Drug Administration (FDA) recently identified the need for more data on the health risk of mercury exposure from dental amalgam among susceptible populations. We evaluated impacts of low level mercury exposure on renal function and neurobehavioral and neuropsychological performance among children. Dental histories for 403 children aged 7-11 years in five schools from Xuhui, Shanghai were checked by dentists. Of them, 198 with confirmed amalgam fillings were recruited (exposure group). Reference children (N=205) were those who never had dental amalgam treatment. In May 2004, each child provided a urine sample for measurements of total mercury, n-acetyl-β-D-glucosaminidase activity, microalbumin, and creatinine (Cr). The Child Behavior Checklist, Eysenck Personality Questionnaire, and an intelligence screening test were administered. The geometric mean urinary mercury concentration was 1.6 μg/g Cr for children with and 1.4 μg/g Cr for children without amalgam fillings. No differences were found between children with and without fillings for either renal function biomarker, or on neurobehavioral, neuropsychological, or intelligence tests. Although urinary mercury concentration was slightly elevated among children with amalgam fillings, we found no evidence of adverse effects on the outcomes evaluated. These results agree with those from recent trials in developed countries.
登录
查看更多内容
影响因子：
120.7
作者：
DeRouen, TA;Martin, MD;Martins, IP
通讯作者：
Martins, IP
DOI：
10.1016/j.ijheh.2005.11.006
发表时间：
2006-07-01
影响因子：
6
作者：
Bates, Michael N.
通讯作者：
Bates, Michael N.
DOI：
10.1080/15287390306384
发表时间：
2003-05-09
影响因子：
2.6
作者：
de Burbure, C;Buchet, JP;Mutti, A
通讯作者：
Mutti, A
影响因子：
1.3
作者：
Achenbach, T M;Ruffle, T M
通讯作者：
Ruffle, T M
影响因子：
10.4
作者：
de Burbure C;Buchet JP;Leroyer A;Nisse C;Haguenoer JM;Mutti A;Smerhovsky Z;Cikrt M;Trzcinka-Ochocka M;Razniewska G;Jakubowski M;Bernard A
通讯作者：
Bernard A