Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levels.
Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levels.
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DOI：
10.1289/ehp.8202
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发表时间：
2006-04
影响因子：
10.4
通讯作者：
Bernard A
中科院分区：
文献类型：
--
作者：
de Burbure C;Buchet JP;Leroyer A;Nisse C;Haguenoer JM;Mutti A;Smerhovsky Z;Cikrt M;Trzcinka-Ochocka M;Razniewska G;Jakubowski M;Bernard A
铅、镉、汞和砷是工业化国家常见的环境污染物，但它们对儿童健康的综合影响却鲜为人知。在一项横断面的欧洲调查中，我们研究了他们对两个主要目标的影响，肾脏和多巴胺能系统。对照和暴露儿童是从法国、捷克共和国和波兰历史上有色冶炼厂附近的居民中招募的。儿童提供血液和尿液样本，用于测定金属和敏感的肾脏或神经生物标志物。血清肌酐、胱抑素C和β2微球蛋白浓度与血铅水平（PbB）呈负相关，提示早期肾超滤平均为PbB水平上四分位数的7% （55 μg/L，平均78.4 μg/L）。尿中视黄醇结合蛋白、克拉拉细胞蛋白和n -乙酰-β-d-氨基葡萄糖苷酶的排泄主要与血或尿中的镉水平和尿汞有关。所有四种金属都影响多巴胺能标记物血清催乳素和尿同香草酸，复杂的相互作用被揭示出来。污染环境的重金属可以对儿童的肾脏和多巴胺能系统造成微妙的影响，但没有明确的证据表明阈值，这加强了控制和调节重金属污染潜在来源的必要性。
Lead, cadmium, mercury, and arsenic are common environmental pollutants in industrialized countries, but their combined impact on children’s health is little known. We studied their effects on two main targets, the renal and dopaminergic systems, in > 800 children during a cross-sectional European survey. Control and exposed children were recruited from those living around historical nonferrous smelters in France, the Czech Republic, and Poland. Children provided blood and urine samples for the determination of the metals and sensitive renal or neurologic biomarkers. Serum concentrations of creatinine, cystatin C, and β2-microglobulin were negatively correlated with blood lead levels (PbB), suggesting an early renal hyperfiltration that averaged 7% in the upper quartile of PbB levels (> 55 μg/L; mean, 78.4 μg/L). The urinary excretion of retinol-binding protein, Clara cell protein, and N-acetyl-β-d-glucosaminidase was associated mainly with cadmium levels in blood or urine and with urinary mercury. All four metals influenced the dopaminergic markers serum prolactin and urinary homovanillic acid, with complex interactions brought to light. Heavy metals polluting the environment can cause subtle effects on children’s renal and dopaminergic systems without clear evidence of a threshold, which reinforces the need to control and regulate potential sources of contamination by heavy metals.
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DOI：
10.1080/15287390306384
发表时间：
2003-05-09
影响因子：
2.6
作者：
de Burbure, C;Buchet, JP;Mutti, A
通讯作者：
Mutti, A
DOI：
10.1097/01.asn.0000064947.14997.69
发表时间：
2003-06-01
影响因子：
13.6
作者：
Courtois, E;Marques, M;López-Farré, A
通讯作者：
López-Farré, A
影响因子：
3.5
作者：
Delgado, JM;Dufour, L;Jiménez-Capdeville, ME
通讯作者：
Jiménez-Capdeville, ME
DOI：
10.1007/s004200050050
发表时间：
1996-03-01
影响因子：
3
作者：
Jakubowski, M;TrzcinkaOchocka, M;Starek, A
通讯作者：
Starek, A
影响因子：
6.1
作者：
Fels, LM;Wunsch, M;Stolte, H
通讯作者：
Stolte, H