Traditional Chinese Medicine Protects against Cytokine Production as the Potential Immunosuppressive Agents in Atherosclerosis.
Traditional Chinese Medicine Protects against Cytokine Production as the Potential Immunosuppressive Agents in Atherosclerosis.
复制标题
中药可防止细胞因子的产生，细胞因子是动脉粥样硬化的潜在免疫抑制剂
DOI：
10.1155/2017/7424307
复制
发表时间：
2017
影响因子：
4.1
通讯作者：
Liu Z
中科院分区：
文献类型：
--
作者：
Ren Y;Qiao W;Fu D;Han Z;Liu W;Ye W;Liu Z
动脉粥样硬化是一种由血脂异常引起的慢性炎症性疾病，由先天性和适应性免疫反应介导。炎症是动脉粥样硬化进展各个阶段的关键因素。促炎细胞因子加速动脉粥样硬化的进展，而抗炎细胞因子改善疾病。因此，抑制免疫激活和阻碍对抗炎活性的免疫应答的策略是常规化疗对心脑血管结局的替代治疗策略。由于传统上已经使用许多中药植物来预防和治疗动脉粥样硬化，因此合理的假设是，用于这种疾病的植物可能会抑制免疫反应和由此产生的炎症。本文综述了近年来对炎性细胞因子爆发具有免疫调节作用的植物及其在中药防治动脉粥样硬化中的应用。
Atherosclerosis is a chronic inflammatory disease caused by dyslipidemia and mediated by both innate and adaptive immune responses. Inflammation is a critical factor at all stages of atherosclerosis progression. Proinflammatory cytokines accelerate atherosclerosis progression, while anti-inflammatory cytokines ameliorate the disease. Accordingly, strategies to inhibit immune activation and impede immune responses towards anti-inflammatory activity are an alternative therapeutic strategy to conventional chemotherapy on cardiocerebrovascular outcomes. Since a number of Chinese medicinal plants have been used traditionally to prevent and treat atherosclerosis, it is reasonable to assume that the plants used for such disease may suppress the immune responses and the resultant inflammation. This review focuses on plants that have immunomodulatory effects on the production of inflammatory cytokine burst and are used in Chinese traditional medicine for the prevention and therapy of atherosclerosis.
登录
查看更多内容
DOI：
10.3390/molecules201219826
发表时间：
2015-12-09
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Hosoo S;Koyama M;Kato M;Hirata T;Yamaguchi Y;Yamasaki H;Wada A;Wada K;Nishibe S;Nakamura K
通讯作者：
Nakamura K
影响因子：
5.3
作者：
Bhaskar, Vinay;Yin, Johnny;Kantak, Seema S.
通讯作者：
Kantak, Seema S.
DOI：
10.1073/pnas.87.13.5134
发表时间：
1990-07-01
影响因子：
11.1
作者：
CUSHING, SD;BERLINER, JA;FOGELMAN, AM
通讯作者：
FOGELMAN, AM
影响因子：
17.1
作者：
Kamaly, Nazila;Fredman, Gabrielle;Fojas, Jhalique Jane R.;Subramanian, Manikandan;Choi, Won Ii;Zepeda, Katherine;Vilos, Cristian;Yu, Mikyung;Gadde, Suresh;Wu, Jun;Milton, Jaclyn;Leitao, Renata Carvalho;Fernandes, Livia Rosa;Hasan, Moaraj;Gao, Huayi;Vance Nguyen;Harris, Jordan;Tabas, Ira;Farokhzad, Omid C.
通讯作者：
Farokhzad, Omid C.
影响因子：
5.8
作者：
Chi, YS;Cheon, BS;Kim, HP
通讯作者：
Kim, HP