Montreal cognitive assessment performance in patients with Parkinson's disease with "normal" global cognition according to mini-mental state examination score.
Montreal cognitive assessment performance in patients with Parkinson's disease with "normal" global cognition according to mini-mental state examination score.
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DOI：
10.1111/j.1532-5415.2008.02096.x
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发表时间：
2009-02
影响因子：
6.3
通讯作者：
Weintraub D
中科院分区：
文献类型：
--
作者：
Nazem S;Siderowf AD;Duda JE;Have TT;Colcher A;Horn SS;Moberg PJ;Wilkinson JR;Hurtig HI;Stern MB;Weintraub D
目的：根据迷你精神状态检查（MMSE）评分，对全球认知“正常”的帕金森病（PD）患者进行蒙特利尔认知评估（MoCA）。MoCA和MMSE的横断面比较。宾夕法尼亚大学的两个运动障碍中心和费城退伍军人事务医疗中心。对131例特发性PD患者进行了认知和精神并发症筛查。受试者接受MoCA和MMSE测试，只有年龄和教育调整后MMSE得分正常的受试者才被纳入分析（N = 100）。正如之前推荐的，在没有PD的患者中，MoCA评分低于26分表明存在至少轻度认知障碍（MCI）。平均MMSE和MoCA评分±标准差分别为28.8±1.1和24.9±3.1。超过一半（52.0%）MMSE评分正常的受试者存在MoCA评分的认知障碍。许多认知领域都出现了损伤，包括记忆、视觉空间和执行能力、注意力和语言。单变量分析MoCA认知障碍的预测因子为男性、年龄较大、教育程度较低和疾病严重程度较高；在多变量模型中，年龄是唯一的预测因子。根据推荐的MoCA截止评分，大约一半MMSE评分正常的PD患者存在认知障碍。这些结果表明，MCI在PD中很常见，MoCA是一种比MMSE更敏感的检测工具。
To examine Montreal Cognitive Assessment (MoCA) performance in patients with Parkinson’s disease (PD) with “normal” global cognition according to Mini-Mental State Examination (MMSE) score. A cross-sectional comparison of the MoCA and the MMSE. Two movement disorders centers at the University of Pennsylvania and the Philadelphia Veterans Affairs Medical Center. A convenience sample of 131 patients with idiopathic PD who were screened for cognitive and psychiatric complications. Subjects were administered the MoCA and MMSE, and only subjects defined as having a normal age- and education-adjusted MMSE score were included in the analyses (N = 100). As previously recommended in patients without PD, a MoCA score less than 26 was used to indicate the presence of at least mild cognitive impairment (MCI). Mean MMSE and MoCA scores ± standard deviation were 28.8 ± 1.1 and 24.9 ± 3.1, respectively. More than half (52.0%) of subjects with normal MMSE scores had cognitive impairment according to their MoCA score. Impairments were seen in numerous cognitive domains, including memory, visuospatial and executive abilities, attention, and language. Predictors of cognitive impairment on the MoCA using univariate analyses were male sex, older age, lower educational level, and greater disease severity; older age was the only predictor in a multivariate model. Approximately half of patients with PD with a normal MMSE score have cognitive impairment based on the recommended MoCA cutoff score. These results suggest that MCI is common in PD and that the MoCA is a more sensitive instrument than the MMSE for its detection.
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影响因子：
2.5
作者：
Pirozzolo, F J;Hansch, E C;Kuskowski, M A
通讯作者：
Kuskowski, M A
影响因子：
6.7
作者：
Athey, RJ;Porter, RW;Walker, RW
通讯作者：
Walker, RW
影响因子：
9.9
作者：
Marinus, J;Visser, M;van Hilten, JJ
通讯作者：
van Hilten, JJ
影响因子：
--
作者：
Aarsland, D;Andersen, K;Kragh-Sorensen, P
通讯作者：
Kragh-Sorensen, P
影响因子：
9.9
作者：
Muslimovic, D;Post, B;Schmand, B
通讯作者：
Schmand, B