Old macrophages lose their (circadian) rhythm.

Old macrophages lose their (circadian) rhythm.
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DOI:
10.1016/j.it.2022.02.005
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发表时间:
2022-04
影响因子:
16.8
通讯作者:
Hargreaves, Diana C. C.
Hargreaves, Diana C. C.
中科院分区:
医学1区
文献类型:
--
作者:
McRae, Helen M. M.;Hargreaves, Diana C. C.

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Blacher及其同事发现,存在于年轻小鼠中的巨噬细胞基因表达和免疫功能的昼夜节律模式在老龄小鼠中被破坏。KLF4被鉴定为调节免疫基因节律性表达的关键转录因子(TF),其在老年巨噬细胞中丢失。
Blacher and colleagues have discovered that the circadian patterns of macrophage gene expression and immune function that exist in young mice are disrupted in aging mice. KLF4 was identified as a key transcription factor (TF) regulating rhythmic expression of immune genes, which is lost in old macrophages.
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