Circadian control of the immune system.

Circadian control of the immune system.
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DOI:
10.1038/nri3386
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发表时间:
2013-03
期刊:
Nature reviews. Immunology
影响因子:
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其他
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昼夜节律长期以来一直被认为在生理学中发挥着至关重要的作用,现在正在成为特定免疫功能的重要调节剂。免疫介质的昼夜节律波动与免疫系统的活动一致,可能使宿主能够更有效地预测和处理微生物威胁。这些振荡还可能有助于促进组织恢复和清除循环中潜在有害的细胞成分。这篇综述总结了免疫系统昼夜节律的当前知识,并对未来的潜在影响进行了展望。
Circadian rhythms, which have long been known to play crucial roles in physiology, are emerging as important regulators of specific immune functions. Circadian oscillations of immune mediators coincide with the activity of the immune system, possibly allowing the host to anticipate and handle microbial threats more efficiently. These oscillations may also help to promote tissue recovery and the clearance of potentially harmful cellular elements from the circulation. This Review summarizes the current knowledge of circadian rhythms in the immune system and provides an outlook on potential future implications.
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