Nerve replacement strategies for cavernous nerves.
Nerve replacement strategies for cavernous nerves.
复制标题
海绵体神经的神经替代策略。
DOI：
10.1016/j.eururo.2005.04.025
复制
发表时间：
2005
期刊：
影响因子：
23.4
通讯作者：
N. Weidner
中科院分区：
文献类型：
--
作者：
F. May;M. Vroemen;K. Matiasek;J. Henke;T. Brill;A. Lehmer;M. Apprich;W. Erhardt;S. Schoeler;R. Paul;A. Blesch;R. Hartung;B. Gansbacher;N. Weidner
目的本文回顾了可用于在骨盆手术时替代切除的海绵体神经的新型海绵体神经恢复疗法。方法基于文献的介绍（Medline 搜索）目前的神经替代策略，重点是有助于海绵体神经损伤后恢复勃起功能的神经生物学因素。结果是自体神经的有前途的替代方案 用于延长成功神经再生时间的移植物是人工神经导管。添加神经营养因子、细胞外基质成分和施万细胞已被证明可以促进海绵体神经再生。神经营养因子可以掺入支架中或可以由接种到基质中的细胞提供。通过神经营养因子编码基因的基因修饰可以进一步增强这些细胞的再生能力。结论人工神经导管，特别是含有生长促进因子或细胞的可生物降解的人工神经导管，是修复海绵神经病变的有前途的选择。
OBJECTIVEThis article reviews novel restorative therapies for cavernous nerves that may be used to replace resected cavernous nerves at the time of pelvic surgery.METHODSA literature-based presentation (Medline search) on current nerve replacement strategies was conducted with emphasis on neurobiological factors contributing to the restoration of erectile function after cavernous nerve injuries.RESULTSA promising alternative to autologous nerve grafts for extending the length of successful nerve regeneration are artificial nerve guides. The addition of neurotrophic factors, extracellular matrix components and Schwann cells has been shown to promote cavernous nerve regeneration. Neurotrophic factors can be incorporated in the scaffold or can be supplied by cells seeded into the stroma. The regenerative capacity of these cells can be further enhanced by genetic modification with neurotrophic factor encoding genes.CONCLUSIONSArtificial nerve guides, especially biodegradable ones containing growth-promoting factors or cells, are a promising option for the repair of cavernous nerve lesions.
影响因子：
6.6
作者：
Burnett, AL;Becker, RE
通讯作者：
Becker, RE
影响因子：
3.3
作者：
M. Tuszynski;N. Weidner;M. Mccormack;I. Miller;H. Powell;J. Conner
通讯作者：
M. Tuszynski;N. Weidner;M. Mccormack;I. Miller;H. Powell;J. Conner
影响因子：
6.6
作者：
Bakircioglu, ME;Lin, CS;Lue, TF
通讯作者：
Lue, TF