Role of nitric oxide-related mechanisms in renal function in ageing rats.
Role of nitric oxide-related mechanisms in renal function in ageing rats.
复制标题
一氧化氮相关机制在衰老大鼠肾功能中的作用。
DOI：
10.1093/ndt/13.3.594
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
C. Caramelo
中科院分区：
文献类型：
--
作者：
D. Tan;M. Cernadas;P. Aragoncillo;M. A. Castilla;M. V. Alvarez Arroyo;A. L. López Farré;S. Casado;C. Caramelo
BACKGROUND
The impaired renal function and vasodilatation that accompany age need to be re-addressed based upon the new knowledge concerning vascular nitric oxide (NO)-dependent systems. The present study examined the effects of age on the NO-related renal response.
METHODS
The study was performed in euvolaemic, conscious Wistar rats, aged 5 and 18 months. Renal function and haemodynamic measurements with fluorescent microspheres were employed to assess differences between groups.
RESULTS
A first set of experiments showed that ageing rats had a reduced natriuretic and diuretic response to acetylcholine, whereas the response to sodium nitroprusside was preserved. In the same regard, a reduction of the renal functional effects of L-arginine (L-Arg) and L-glycine (L-Gly) was found in the older rats. In the ageing rats, these responses were accompanied by an enhanced effect of the L-Arg competitive analogue, NwNLA, which provoked a marked reduction of renal function. This effect of NwNLA was blocked by the simultaneous administration of a small dose of L-Arg in the ageing but not in the young rats. Systemic haemodynamic studies revealed that in ageing rats, NwNLA reduced renal blood flow and increased renal vascular resistances in a significantly higher proportion than in younger animals. However, flow to other organs, namely, brain, spleen or liver, was affected in a similar manner in both young and old rats. Ultrastructural alterations were found in endothelial cells, which might constitute the anatomical basis for the observed functional derangements.
CONCLUSIONS
The present experiments reveal that ageing is accompanied by significant differences in NO-related responses in the kidney which do not appear to affect blood flow to other organs. The response to L-Arg and L-Arg competitive analogues supports the existence of a marked dependency on NO-related mechanisms in the ageing rats, but not of a decreased baseline activity of the NO-dependent pathways.
内皮源性一氧化氮在控制老年雄性大鼠肾微血管中的作用。
DOI：
10.1152/ajpregu.1993.265.5.r1126
发表时间：
1993
期刊：
The American journal of physiology
影响因子：
--
作者：
Reckelhoff,JF;ManningJr,RD
通讯作者：
ManningJr,RD
衰老大鼠肾脏对静脉注射甘氨酸的肾血管舒张反应。
DOI：
10.1016/s0272-6386(12)80769-4
发表时间：
1990
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Baylis,C;Fredericks,M;Wilson,C;Munger,K;Collins,R
通讯作者：
Collins,R
影响因子：
3.3
作者：
GLENNY, RW;BERNARD, S;BRINKLEY, M
通讯作者：
BRINKLEY, M